Multimodal architectonic subdivision of the caudal ventrolateral prefrontal cortex of the macaque monkey
Multimodal architectonic subdivision of the caudal ventrolateral prefrontal cortex of the macaque monkey
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DOI：
10.1007/s00429-007-0158-9
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发表时间：
2007-12-01
影响因子：
3.1
通讯作者：
Luppino, Giuseppe
中科院分区：
文献类型：
--
作者：
Gerbella, Marzio;Belmalih, Abdelouahed;Luppino, Giuseppe
猕猴腹外侧前额叶皮层（VLPF）的尾侧部分是几个功能不同的区域的一部分。在本研究中，我们基于SMI-32和Calbindin免疫反应性的分布，结合了细胞和骨髓结构法和化学结构法，以确定占据该区域的不同结构区域的数量和范围。确定了几个结构上不同的区域，全部或部分位于尾侧VLPF。两个区域几乎完全局限于下弓状沟的前岸，一个背侧1 -8/ fef，它也更向后延伸，应该代表额眼视野的结构对应物，一个腹侧1 - 45b，它占据了腹侧的一半。另外两个区域占据腹侧弓形前凸皮层，一个位于8/FEF区吻侧的尾端区域8r和一个延伸至额下沟的吻侧区域45a。45A区在背侧靠近主沟，与46区接壤，在腹侧与12区接壤。目前的数据显示存在两个不同的预凸区（8r和45A），扩展了尾侧VLPF的其他结构细分，并为该区域提供了一个新的多结构参考框架。目前的结构数据以及其他功能和连接数据表明，8/FEF区、45B区和8r区是眼动额叶皮层的一部分，而45A区是VLPF区域的一个独立实体，参与非空间信息的高阶处理。
The caudal part of the macaque ventrolateral prefrontal cortex (VLPF) is part of several functionally distinct domains. In the present study we combined a cyto- and a myeloarchitectonic approach with a chemoarchitectonic approach based on the distribution of SMI-32 and Calbindin immunoreactivity, to determine the number and extent of architectonically distinct areas occupying this region. Several architectonically distinct areas, completely or partially located in the caudal VLPF, were identified. Two areas are almost completely limited to the anterior bank of the inferior arcuate sulcus, a dorsal one-8/FEF-which extends also more dorsally and should represent the architectonic counterpart of the frontal eye field, and a ventral one-45B-which occupies the ventral half of the bank. Two other areas occupy the ventral prearcuate convexity cortex, a caudal one-area 8r-located just rostral to area 8/FEF and a rostral one-area 45A-which extends as far as the inferior frontal sulcus. Area 45A borders dorsally, in the proximity of the principal sulcus, with area 46 and, ventrally, with area 12. The present data show the existence of two distinct prearcuate convexity areas (8r and 45A), extending other architectonic subdivisions of the caudal VLPF and providing a new, multiarchitectonic frame of reference for this region. The present architectonic data, together with other functional and connectional data, suggest that areas 8/FEF, 45B and 8r are part of the oculomotor frontal cortex, while area 45A is a distinct entity of the VLPF domain involved in high-order processing of nonspatial information.