Chasing Mavericks: The quest for defining developmental waves of hematopoiesis.
Chasing Mavericks: The quest for defining developmental waves of hematopoiesis.
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DOI：
10.1016/bs.ctdb.2019.01.001
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发表时间：
2019
影响因子：
--
通讯作者：
Forsberg, E. Camilla
中科院分区：
文献类型：
--
作者：
Cool, Taylor;Forsberg, E. Camilla
造血是由造血干细胞和祖细胞（造血干细胞和造血干细胞）产生成熟血液细胞和免疫细胞的过程。过去几十年的研究已经阐明了造血干细胞的起源，以及促进终身造血的异质胎儿祖细胞池。多年来，造血发生在整个发育过程中是动态的、重叠的，每一波都有助于连续的和发育受限的细胞类型，这一总体概念已经得到了巩固。然而，最近我们在体内追踪造血细胞产生能力方面的进展挑战了几个长期以来关于不同造血细胞类型的起源和持久性的教条。在这篇综述中，我们强调了造血发育的新兴概念，并确定了未解决的问题。
Hematopoiesis is the process by which mature blood and immune cells are produced from hematopoietic stem and progenitor cells (HSCs and HSPCs). The last several decades of research have shed light on the origin of HSCs, as well as the heterogeneous pools of fetal progenitors that contribute to lifelong hematopoiesis. The overarching concept that hematopoiesis occurs in dynamic, overlapping waves throughout development, with each wave contributing to both continuous and developmentally limited cell types, has been solidified over the years. However, recent advances in our ability to track the production of hematopoietic cells in vivo has challenged several long-held dogmas on the origin and persistence of distinct hematopoietic cell types. In this review, we highlight emerging concepts in hematopoietic development and identify unanswered questions.
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影响因子：
64.8
作者：
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通讯作者：
Speck, Nancy A.
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作者：
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通讯作者：
MCCULLOCH, EA