Adipokines and cytokines in non-alcoholic fatty liver disease
Adipokines and cytokines in non-alcoholic fatty liver disease
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DOI：
10.1111/j.1365-2036.2007.03586.x
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发表时间：
2008-03-01
影响因子：
7.6
通讯作者：
Younossi, Z. M.
中科院分区：
文献类型：
--
作者：
Jarrar, M. H.;Baranova, A.;Younossi, Z. M.
几种脂肪细胞因子与非酒精性脂肪性肝病（NAFLD）的发病机制有关。目的评价NAFLD患者和对照组的脂肪细胞因子水平。方法纳入95例患者，其中非酒精性脂肪性肝炎（NASH） 26例，单纯性脂肪变性（SS） 19例，肥胖对照组38例，非肥胖对照组12例。测定空腹血清胰岛素、血糖、胰脂素、抵抗素、脂联素、肿瘤坏死因子- α (tnf - α)、白细胞介素-8 （IL-8）、IL-6。单变量和多变量分析用于组间比较和确定相关性。结果NAFLD患者血清TNF-a和IL-8均高于肥胖和非肥胖对照组。对所有患者的分析显示，血清tnf - α与IL-8 （P < 6.319e-08）、IL-6与IL-8 （P < 5.271e-15）之间存在显著相关性。稳态模型评分与NAFLD患者脂联素呈负相关（P < 0.0032）。肥胖组血清visfatin均高于非肥胖组（P < 0.02, P < 0.002和P < 0.008）。NASH患者的Visfatin低于SS和肥胖对照组。虽然tnf - α与NAFLD相关（P < 0.02），但它与visfatin相互依赖。与SS相比，年龄、丙氨酸转氨酶、IL-8、脂联素4个因素与NASH独立相关（P < 0.05）。多因素分析表明，tnf - α是NASH纤维化的唯一独立预测因子（P < 0.0004）。结论脂肪细胞因子与NAFLD发病机制之间存在复杂的相互作用。
BackgroundSeveral adipocytokines have been implicated in the pathogenesis nonalcoholic fatty liver disease (NAFLD).AimTo assess adipocytokines in NAFLD patients and controls.MethodsA total of 95 patients (26 non-alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non-obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and IL-6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations.ResultsSerum TNF-a and IL-8 were higher in NAFLD patients when compared with both obese and non-obese controls. Analysis involving all patients revealed a significant correlation between serum TNF-alpha and IL-8 (P < 6.319e-08), and between IL-6 and IL-8 (P < 5.271e-15). Homeo-static model assessment scores negatively correlated with adiponectin in NAFLD (P < 0.0032). Serum visfatin was higher in all three obese groups than in non-obese controls (P < 0.02, P < 0.002 and P < 0.008). Visfatin in NASH patients was lower than SS and obese controls. Although TNF-alpha was associated with NAFLD (P < 0.02), it was interdependent on visfatin. In comparison to SS, four factors were independently associated with NASH: age, alanine aminotransferase, IL-8 and adiponectin (P < 0.05). Multivariate analysis indicated that TNF-alpha was the only independent predictor of fibrosis in NASH (P < 0.0004).ConclusionThese findings support a complex interaction between adipocytokines and the pathogenesis of NAFLD.