Metabolic abnormalities are present in adults with elevated serum cystatin C.
Metabolic abnormalities are present in adults with elevated serum cystatin C.
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DOI：
10.1038/ki.2009.76
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发表时间：
2009-07
影响因子：
19.6
通讯作者：
Fox, Caroline S.
中科院分区：
文献类型：
--
作者：
Muntner, Paul;Vupputuri, Suma;Coresh, Josef;Uribarri, Jaime;Fox, Caroline S.
血清胱抑素C升高可能代表肾脏疾病的早期阶段。目前尚不清楚肾小球滤过率≥60ml /min/1.73m2且胱抑素C升高的晚期慢性肾病患者是否存在典型的代谢异常。第三次全国健康与营养调查（n=6722）的参与者分为三组：肾小球滤过率≥60ml /min/1.73m2，胱抑素C <1.09 mg/L（正常胱抑素C）；估计肾小球滤过率≥60ml /min/1.73m2，胱抑素C≥1.09 mg/L（胱抑素C升高）；估计肾小球滤过率为15-59 ml/min/1.73m2（慢性肾病3期或4期）。在胱抑素C正常、胱抑素C升高和3期或4期慢性肾病患者中，年龄、种族、性别标准化血清血红蛋白<12 g/dL（男性<13 g/dL）的患病率分别为4.3%、8.2%和13.8%；血清尿酸≥5.9 mg/dL（男性≥7.4 mg/dL）分别为12.6%、30.0%和45.0%；血清同型半胱氨酸≥13 μmol/L分别为12.1%、25.1%和41.0%；血清磷≥3.9 mg/dL分别为17.2%、23.2%和25.8%；血清白蛋白<3.8 mg/dL分别为14.5%、20.0%和20.4%；血浆纤维蛋白原≥352 mg/dL分别为10.5%、21.7%和23.2%；c反应蛋白≥1.0 g/dL分别为7.5%、22.5%和21.6% （p趋势均<0.001）。在肾小球滤过率≥60 ml/min/1.73m2的成年人中，血清胱抑素C升高与几种代谢异常的患病率增加有关。
Elevated serum cystatin C may represent an early stage of kidney disease. It is unclear whether metabolic abnormalities typically seen in advanced chronic kidney disease are present in adults with estimated glomerular filtration rate ≥60 ml/min/1.73m2 and elevated cystatin C. Participants of the Third National Health and Nutrition Examination Survey (n=6722) were categorized into three groups: estimated glomerular filtration rate ≥ 60 ml/min/1.73m2 and cystatin C <1.09 mg/L (normal cystatin C); estimated glomerular filtration rate ≥60 ml/min/1.73m2 and cystatin C ≥1.09 mg/L (elevated cystatin C); and estimated glomerular filtration rate of 15-59 ml/min/1.73m2 (stage 3 or 4 chronic kidney disease). Among those with normal cystatin C, elevated cystatin C, and stage 3 or 4 chronic kidney disease, the age, race-ethnicity, sex standardized prevalence of serum hemoglobin <12 g/dL (<13 g/dL for men) was 4.3%, 8.2%, and 13.8%; serum uric acid ≥ 5.9 mg/dL (≥7.4 mg/dL for men) was 12.6%, 30.0%, and 45.0%; serum homocysteine ≥13 μmol/L was 12.1%, 25.1%, and 41.0%; serum phosphorus ≥3.9 mg/dL was 17.2%, 23.2%, and 25.8%; serum albumin <3.8 mg/dL was 14.5%, 20.0%, and 20.4%; plasma fibrinogen ≥352 mg/dL was 10.5%, 21.7%, and 23.2%; and C-reactive protein ≥1.0 g/dL was 7.5%, 22.5%, and 21.6% (each p-trend<0.001). Among adults with estimated glomerular filtration rate ≥60 ml/min/1.73m2, elevated serum cystatin C is associated with an increased prevalence of several metabolic abnormalities.
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影响因子：
13.2
作者：
Koettgen, Anna;Selvin, Elizabeth;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
5.9
作者：
Muntner, Paul;Winston, Jonathan;Fox, Caroline S.
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Fox, Caroline S.
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作者：
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通讯作者：
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