Primates and anencephalics as sources for pediatric organ transplants. Medical, legal, and ethical issues.
Primates and anencephalics as sources for pediatric organ transplants. Medical, legal, and ethical issues.
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灵长类动物和无脑动物作为儿科器官移植的来源。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
M. Harrison
中科院分区：
文献类型：
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作者：
J. Fletcher;J. Robertson;M. Harrison
这篇文章讨论了使用灵长类和无脑者的器官移植到否则会死亡的婴儿身上的一些医学、法律和伦理问题。出于伦理原因，使用灵长类动物是不受欢迎的，因为黑猩猩是首选物种，而且生存的机会很小。如果符合伦理和法律方面的考虑，无脑胎儿和新生儿是很有希望的儿科移植器官来源。根据目前临终供者的管理实践，提出了符合法律要求的器官摘除，直到全脑死亡后；然而，这种方法需要对新出生的无脑症患者的身体进行逐渐降温的补偿步骤，以保护器官免受缺血。
This article discusses some of the medical, legal, and ethical issues in using organs from primates and anencephalics to transplant to infants who will otherwise die. The use of primates is discouraging on ethical grounds due to scarcity of chimpanzees, the preferred species, and to the poor chance of survival. Anencephalic fetuses and newborns are promising sources of organs for pediatric transplants, provided that ethical and legal considerations are met. An argument is made, based on current practice in management of dying donors, that complies with the legal requirement to delay organ removal until after whole brain death; however, this approach requires the compensating step of gradual cooling of the body of the newly delivered anencephalic to save the organs from ischemia.