ChAdOx1 nCoV-19 vaccine: asymptomatic efficacy estimates.
ChAdOx1 nCoV-19 vaccine: asymptomatic efficacy estimates.
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ChAdOx1 nCoV-19 疫苗：无症状疗效估计。
DOI：
10.1016/s0140-6736(21)00951-x
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Platts-Mills,JamesA
中科院分区：
文献类型：
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作者：
McQuade,ElizabethTRogawski;Platts-Mills,JamesA
也门是世界上卫生系统最脆弱的国家之一，目前正经历着战争和饥荒。自2015年以来，该国的人道主义危机导致了令人衰弱的传染病的出现和重新出现，并严重削弱了该国的卫生基础设施。2020年4月也门报告了第一例COVID-19病例，世卫组织警告可能会出现灾难性的病例爆炸。1早期的流行病学数据显示，60岁以下的人死亡率很高。2由于缺乏设备齐全的实验室、基础设施和检测工具，误诊和低估新病例导致报告病例数不一致。事实上，最近对大流行期间亚丁省埋葬活动的地理空间分析3表明，COVID-19的影响巨大且未被充分确定，这意味着报告的死亡率数据不准确。也门预计将通过COVAX获得1400万剂COVID-19疫苗，足以为约23%的人口接种疫苗。5根据OurWorldInData COVID-19疫苗接种仪表板，截至2021年5月29日，超过104 000人已接种至少一剂COVID-19疫苗。考虑到所有因素，重要的是要在也门建立一个安全的疫苗接种模式，也门是一个没有追踪病毒在易感社区传播的系统的国家。值得注意的是，也门人口中只有不到3%的人超过65岁，与许多其他国家相比，这一比例相对较小。
Yemen has one of the most fragile health-care systems and is currently experiencing war and famine. Since 2015, the country’s humanitarian crisis has resulted in the emergence and reemergence of debilitating infectious diseases and severely weakened the country’s health infrastructure. The first COVID-19 case in Yemen was reported in April, 2020, and WHO warned of a possible catastrophic explosion of cases. 1 Early epidemiological data showed a high mortality rate in individuals younger than 60 years. 2 In the absence of well equipped laboratories, infrastructure, and testing tools, misdiagnoses and underestimation of new cases have resulted in inconsistencies in reported case numbers. Indeed, a recent geospatial analysis of burial activity in the Aden governorate3 during the pandemic suggested a substantial, under-ascertained impact of COVID-19, implying that reported mortality data are inaccurate.According to the latest WHO Yemen Situation Report for March, 2021, 4 Yemen has received 360 000 doses of AstraZeneca COVID-19 vaccines through the COVAX initiative. Yemen is expecting to receive 14 million doses of COVID-19 vaccines through the COVAX, enough to vaccinate about 23% of the population. 5 According to OurWorldInData COVID-19 vaccinations dashboard, as of May 29, 2021, just over 104 000 people have received at least one dose of COVID-19 vaccine. All things considered, it is important to fashion out a safe model for vaccination rollout in Yemen, a country without a system for tracking virus spread in its susceptible community. Worthy of note is the fact that just less than 3% of the Yemeni population is older than 65 years, which is relatively small proportion of the population compared with many other