Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients
Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients
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DOI：
10.1016/j.jep.2010.12.045
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发表时间：
2011-03-24
影响因子：
5.4
通讯作者：
Haines, Stuart T.
中科院分区：
文献类型：
--
作者：
Fuangchan, Anjana;Sonthisombat, Paveena;Haines, Stuart T.
民族药理学相关性：苦瓜（苦瓜）已被广泛用作亚洲糖尿病患者的传统药物治疗。在体外和动物研究表明其降血糖活性，但有限的人类研究可支持其use.Aim的研究：这项研究进行了评估的有效性和安全性的三个剂量的苦瓜相比，二甲双胍。材料和方法：这是一个为期4周，多中心，随机，双盲，活性对照试验。患者随机分为4组，分别接受苦瓜500 mg/天、1000 mg/天和2000 mg/天或二甲双胍1000 mg/天治疗。结果：二甲双胍组（-16.8; 95%CI，-31.2，-2.4 μ mol/L）和苦瓜2000 mg/d组（-10.2; 95%CI，-19.1，-1.3 μ mol/L）的果糖胺在第4周时显著下降。苦瓜500和1000毫克/天没有显着降低果糖胺水平（分别为-3.5，95% CI-11.7，4.6和-10.3，95% CI-22.7，2.2 μ mol/L）。苦瓜有适度的降血糖作用，在接受2000 mg/kg的2型糖尿病患者中，天但是，苦瓜的降糖作用小于二甲双胍1000 mg/天。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Ethnopharmacological relevance: Bitter melon (Momordica charantia L) has been widely used as an traditional medicine treatment for diabetic patients in Asia. In vitro and animal studies suggested its hypoglycemic activity, but limited human studies are available to support its use.Aim of study: This study was conducted to assess the efficacy and safety of three doses of bitter melon compared with metformin.Materials and methods: This is a 4-week, multicenter, randomized, double-blind, active-control trial. Patients were randomized into 4 groups to receive bitter melon 500 mg/day, 1000 mg/day, and 2000 mg/day or metformin 1000 mg/day. All patients were followed for 4 weeks.Results: There was a significant decline in fructosamine at week 4 of the metformin group (-16.8; 95% CI, -31.2, -2.4 mu mol/L) and the bitter melon 2000 mg/day group (-10.2; 95% CI, -19.1, -1.3 mu mol/L). Bitter melon 500 and 1000 mg/day did not significantly decrease fructosamine levels (-3.5; 95% CI -11.7, 4.6 and -10.3; 95% CI -22.7, 2.2 mu mol/L, respectively).Conclusions: Bitter melon had a modest hypoglycemic effect and significantly reduced fructosamine levels from baseline among patients with type 2 diabetes who received 2000 mg/day. However, the hypoglycemic effect of bitter melon was less than metformin 1000 mg/day. (C) 2011 Elsevier Ireland Ltd. All rights reserved.