Human autoimmune neuropathies.
Human autoimmune neuropathies.
复制标题
人类自身免疫性神经病。
DOI:
--
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发表时间:
1998
影响因子:
13.9
通讯作者:
J. Griffin
中科院分区:
文献类型:
--
作者:
T. Ho;G. Mckhann;J. Griffin
Peripheral nerve diseases are among the most prevalent disorders of the nervous system. Because of the accessibility of the peripheral nervous system (PNS) to direct physiological and pathological study, neuropathies have traditionally played a unique role in developing our understanding of basic mechanism of nervous system injury and repair. At present they are providing new insight into the mechanisms of immune injury to the nervous system. A rapidly growing catalogue of PNS disorders are now suspected to be immune-mediated, and in the best understood of these disorders, the molecular and cellular targets of immune attack are known, and the pathophysiology follows directly from the specific immune injury. This review summarizes the immunologically relevant features of the PNS, then considers selected immune-mediated neuropathies, focusing on pathogenetic mechanisms. Finally, the PNS is providing a testing ground for new immunotherapies and approaches to protection and regeneration, including the use of trophic factors. The current status of treatment and implications for future approaches is reviewed.
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影响因子:
3
作者:
Sumner,A;Said,G;Idy,I;Metral,S
通讯作者:
Metral,S
DOI:
--
发表时间:
1990-11
期刊:
The Journal of pharmacology and experimental therapeutics
影响因子:
--
作者:
W. Pardridge;D. Triguero;J. Buciak;Jing Yang
通讯作者:
W. Pardridge;D. Triguero;J. Buciak;Jing Yang
影响因子:
14.5
作者:
GRIFFIN, JW;LI, CY;ASBURY, AK
通讯作者:
ASBURY, AK
影响因子:
8.9
作者:
Lennon,VA;Lambert,EH
通讯作者:
Lambert,EH
影响因子:
158.5
作者:
LENNON, VA;KRYZER, TJ;LAMBERT, EH
通讯作者:
LAMBERT, EH