Human autoimmune neuropathies.

Human autoimmune neuropathies.
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人类自身免疫性神经病。

DOI:
--
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发表时间:
1998
影响因子:
13.9
通讯作者:
J. Griffin
J. Griffin
中科院分区:
医学1区
文献类型:
--
作者:
T. Ho;G. Mckhann;J. Griffin

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周围神经疾病是最普遍的神经系统疾病之一。由于周围神经系统(PNS)的直接生理和病理研究的可及性,神经病传统上在发展我们对神经系统损伤和修复的基本机制的理解中发挥了独特的作用。目前,它们为神经系统免疫损伤的机制提供了新的见解。现在,PNS疾病的快速增长的目录被怀疑是免疫介导的,并且在对这些疾病的最佳理解中,免疫攻击的分子和细胞靶点是已知的,并且病理生理学直接从特异性免疫损伤开始。本文综述了PNS的免疫学相关特征,并对免疫介导的PNS神经病变进行了研究,重点介绍了PNS的发病机制。最后,PNS为新的免疫疗法和保护和再生方法提供了试验场,包括使用营养因子。目前的治疗现状和未来的方法的影响进行了审查。
Peripheral nerve diseases are among the most prevalent disorders of the nervous system. Because of the accessibility of the peripheral nervous system (PNS) to direct physiological and pathological study, neuropathies have traditionally played a unique role in developing our understanding of basic mechanism of nervous system injury and repair. At present they are providing new insight into the mechanisms of immune injury to the nervous system. A rapidly growing catalogue of PNS disorders are now suspected to be immune-mediated, and in the best understood of these disorders, the molecular and cellular targets of immune attack are known, and the pathophysiology follows directly from the specific immune injury. This review summarizes the immunologically relevant features of the PNS, then considers selected immune-mediated neuropathies, focusing on pathogenetic mechanisms. Finally, the PNS is providing a testing ground for new immunotherapies and approaches to protection and regeneration, including the use of trophic factors. The current status of treatment and implications for future approaches is reviewed.
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