TRANSCRANIAL MAGNETIC STIMULATION MAPPING OF THE MOTOR CORTEX IN NORMAL SUBJECTS - THE REPRESENTATION OF 2 INTRINSIC HAND MUSCLES
TRANSCRANIAL MAGNETIC STIMULATION MAPPING OF THE MOTOR CORTEX IN NORMAL SUBJECTS - THE REPRESENTATION OF 2 INTRINSIC HAND MUSCLES
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DOI：
10.1016/0022-510x(93)90102-5
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发表时间：
1993-09-01
影响因子：
4.4
通讯作者：
MASTAGLIA, FL
中科院分区：
文献类型：
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作者：
WILSON, SA;THICKBROOM, GW;MASTAGLIA, FL
采用经颅磁刺激（TMS）标测技术，对10名右利手和6名左利手受试者的拇短展肌（APB）和小指展肌（ADM）进行了TMS标测。使用50 mm直径的8字形线圈。使用基于纬度/经度的坐标系定位刺激部位，调节刺激强度阈值，并在目标肌肉的受控低水平（10%）自主收缩期间施加刺激。通过将连续定义的三维函数拟合到从特定头皮部位的刺激获得的数据，并使用径向投影将该函数投影到二维表面上，来生成皮质运动表示的地图。结果发现，APB和ADM的映射表示是大的和重叠的，但有一个统计学上显着的分离的两个领域，APB区被放置在更横向比ADM区。两块肌肉的经颅磁刺激映射图显示，左右半球之间没有显着差异，并且在左利手和右利手受试者中相似。磁线圈旋转90度导致TMS标测图示的内侧移位和延长，但两个区域的相对位置没有变化。TMS映射的表示被认为是非常可重复的映射后，间隔长达181天。本技术的TMS映射允许代表个别的手肌肉在初级运动皮层被可靠地和可重复地映射，并应证明是有用的进一步研究的生理和病理生理的运动皮层在人。
The TMS-mapped representations of two intrinsic hand muscles, abductor pollicis brevis (APB) and abductor digiti minimi (ADM), were quantified using a transcranial magnetic stimulation (TMS) mapping technique in 10 right handed and 6 left handed subjects. A 50 mm diameter figure eight coil was used. Stimulus sites were located using a latitude/longitude based coordinate system, stimulus intensity was threshold-adjusted and stimuli were applied during controlled low-level (10%) voluntary contraction of the target muscles. Maps of the corticomotor representation were generated by fitting a continuously defined three dimensional function to the data obtained from stimulation at specific scalp sites, and projecting this function onto a two dimensional surface using a radial projection. It was found that the mapped representations of APB and ADM were large and overlapping but that there was a statistically significant separation of the two areas, the APB area being more laterally placed than the ADM area. The TMS-mapped representations of the two muscles showed no significant interhemispheric differences and were similar in left and right handed subjects. Rotation of the magnetic coil through 90 degrees resulted in medial shift and elongation of the TMS-mapped representations but there was no change in the relative positions of the two areas. The TMS-mapped representations were found to be very reproducible when mapping was repeated after intervals of up to 181 days. The present technique of TMS mapping allows the representation of individual hand muscles in the primary motor cortex to be reliably and reproducibly mapped and should prove useful for further studies of the physiology and pathophysiology of the motor cortex in man.