Effect of osmotic-release oral system methylphenidate on different domains of attention and executive functioning in children with attention-deficit-hyperactivity disorder
Effect of osmotic-release oral system methylphenidate on different domains of attention and executive functioning in children with attention-deficit-hyperactivity disorder
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DOI：
10.1111/j.1469-8749.2011.03944.x
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发表时间：
2011-09-01
影响因子：
3.8
通讯作者：
Power, Thomas J.
中科院分区：
文献类型：
--
作者：
Blum, Nathan J.;Jawad, Abbas F.;Power, Thomas J.
目的探讨口服哌甲酯缓释系统（OROS）治疗注意缺陷多动障碍（ADHD）患儿是否能改善注意和执行功能.男24例，女6例，平均年龄8岁6个月，标准差1岁11个月;年龄范围6 y 5 mo-12 y 6 mo）的ADHD混合型患者参加了一项双盲、安慰剂对照的交叉试验，采用系统性开放标签滴定程序确定儿童的临床最有效剂量。每次治疗（安慰剂和OROS哌甲酯）1周后，进行神经心理成套测试，评估持续注意力、选择性注意力、注意力控制、反应抑制和工作记忆。结果OROS哌醋甲酯组在三个反应抑制测试中的两个测试中的表现与安慰剂组相比有所改善（p
AIM This study investigated whether components of attention and executive functioning improve when children with attention-deficit-hyperactivity disorder (ADHD) are treated with osmotic-release oral system (OROS) methylphenidate.METHOD Thirty children (24 males, six females; mean age 8y 6mo, SD 1y 11mo; range 6y 5mo - 12y 6mo) with ADHD combined type participated in a double-blind, placebo-controlled crossover trial with the child's clinically most effective dose as identified with a systematic open-label titration procedure. After 1 week on each treatment (placebo and OROS methylphenidate), a neuropsychological battery that assessed sustained attention, selective attention, attentional control, response inhibition, and working memory was administered. This battery included the Gordon Diagnostic System, seven subtests of the Test of Everyday Attention for Children, and two tests of working memory.RESULTS Performance on two of three tests of response inhibition improved on OROS methylphenidate compared with placebo (p