Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49
Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49
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DOI：
10.1074/jbc.272.34.21488
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发表时间：
1997-08-22
影响因子：
4.8
通讯作者：
Perin, MS
中科院分区：
文献类型：
--
作者：
Dodds, DC;Omeis, IA;Perin, MS
我们已经确定了第一个假定的完整膜五聚蛋白，并命名为神经元五聚蛋白受体（NPR）。NPR通过在蛇毒毒素泰泊辛柱和泰泊辛结合蛋白神经元五聚蛋白1（NP 1）、神经元五聚蛋白2（NP 2）和泰泊辛相关钙结合蛋白49（TCBP 49）柱上的亲和色谱法富集。NPR的主要形式含有推定的NH 2-末端跨膜结构域，并且所有形式的NPR都是糖基化的。NPR与NP 1和NP 2分别具有49%和48%的氨基酸同一性，并且NPR信息在表达NP 1和NP 2的神经元区域中表达。我们认为NPR、NP 1、NP 2和TCBP 49参与负责将泰伯辛转运到突触中的途径，并且这可能代表参与突触碎片清除的新的神经元摄取途径。
We have identified the first putative integral membrane pentraxin and named it neuronal pentraxin receptor (NPR). NPR, is enriched by affinity chromatography on columns of a snake venom toxin, taipoxin, and columns of the taipoxin-binding proteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipoxin-associated calcium-binding protein 49 (TCBP49), The predominant form of NPR contains an putative NH2-terminal transmembrane domain and all forms of NPR are glycosylated. NPR has 49 and 48% amino acid identity to NP1 and NP2, respectively, and NPR message is expressed in neuronal regions that express NP1 and NP2, We suggest that NPR, NP1, NP2, and TCBP49 are involved in a pathway responsible for the transport of taipoxin into synapses and that this may represent a novel neuronal uptake pathway involved in the clearance of synaptic debris.