Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis
Use of the quorum-sensing inhibitor RNAIII-inhibiting peptide to prevent biofilm formation in vivo by drug-resistant Staphylococcus epidermidis
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DOI：
10.1086/345879
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发表时间：
2003-02-15
影响因子：
6.4
通讯作者：
Dell'Acqua, G
中科院分区：
文献类型：
--
作者：
Balaban, N;Giacometti, A;Dell'Acqua, G
表皮葡萄球菌是异物和留置医疗器械相关感染的常见原因。细菌能够通过封装成生物膜而在抗生素治疗中存活。RNA Ⅲ抑制肽（RIP）是一种抑制S.金黄色葡萄球菌致病机制通过破坏群体感应机制。在本研究中，RIP抑制耐药S。表皮葡萄球菌生物膜形成的机制与S.金黄色。RIP与抗生素具有协同作用，可100%消除体内移植物相关的沙门氏菌。这表明RIP可用于涂覆医疗器械以防止葡萄球菌感染。细胞间通讯的中断可以预防与耐药菌株相关的感染。
Staphylococcus epidermidis is a frequent cause of infections associated with foreign bodies and indwelling medical devices. The bacteria are capable of surviving antibiotic treatment through encapsulation into biofilms. RNAIII-inhibiting peptide (RIP) is a heptapeptide that inhibits S. aureus pathogenesis by disrupting quorum-sensing mechanisms. In this study, RIP inhibited drug-resistant S. epidermidis biofilm formation through a mechanism similar to that evidenced for S. aureus. RIP is synergistic with antibiotics in eliminating 100% of graft-associated in vivo S. epidermidis infections, which suggests that RIP may be used to coat medical devices to prevent staphylococcal infections. Disruption of cell-cell communication can prevent infections associated with antibiotic-resistant strains.