Exogenous testosterone attenuates the integrated central stress response in healthy young women
Exogenous testosterone attenuates the integrated central stress response in healthy young women
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DOI：
10.1016/j.psyneuen.2007.08.006
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发表时间：
2007-09-01
影响因子：
3.7
通讯作者：
van Honk, Jack
中科院分区：
文献类型：
--
作者：
Hermans, Erno J.;Putman, Peter;van Honk, Jack
动物研究表明，雄激素类固醇睾酮，下丘脑-垂体-性腺（HPG）轴的最终产物，在多个水平下调综合应激反应。这些作用已在杏仁核和终纹床核水平以及沿着下丘脑-垂体-肾上腺（HPA）轴的不同节点得到证实。本研究旨在评估外源性睾酮对人类自主神经系统反应性和声惊吓反射调制的影响。20名健康女性受试者接受了0.5mg睾酮的双盲、安慰剂对照舌下给药。测量相位皮电活动，心脏反应，和惊吓反射声探头，而参与者被暴露在图片强烈厌恶，中性，或积极的内容。还获得了情绪和图片评价的主观报告。结果支持这一假设的压力系统的反应性普遍下降，显示减少皮肤电导反应，以及减少情感惊吓调制焦虑倾向的参与者后，管理睾酮。候选人的神经生物学机制的行动概述和讨论，有人认为，雄激素促进动态调节的压力系统，通过对中枢神经肽能途径，控制促肾上腺皮质激素释放激素（CRH）和精氨酸加压素（AVP）的表达。目前的研究结果强调了进一步研究HPG轴在与HPA轴功能障碍相关的疾病中的可能作用的重要性。(C)2007爱思唯尔有限公司版权所有。
Animal research has shown that the androgen steroid testosterone, the end product of the hypothalamic-pituitary-gonadal (HPG) axis, down regulates the integrated stress response at multiple levels. These effects have been demonstrated at the level of the amygdala and the bed nucleus of the stria terminalis, and along the different nodes of the hypothalamic-pituitary-adrenal (HPA) axis. The present study was designed to assess effects of exogenous testosterone upon reactivity of the autonomic nervous system and modulation of the acoustic startle reflex in humans. Twenty healthy female participants received double-blind, placebo-controlled sublingual administrations of .5mg testosterone. Measurements were made of phasic electrodermal activity, cardiac responses, and startle reflexes to acoustic probes while participants were exposed to pictures with strongly aversive, neutral, or positive content. Subjective reports of mood and picture evaluations were also obtained. Results support the hypothesis of a generally decreased responsiveness of the stress system by showing reduced skin conductance responses as well as reduced affective startle modulation in anxiety-prone participants after administration of testosterone. Candidate neurobiological mechanisms of action are outlined and discussed, and it is argued that androgens promote dynamic regulation of the stress system through actions upon central neuropeptidergic pathways that control corticotropin releasing hormone (CRH) and arginine vasopressin (AVP) expression. The present findings highlight the importance of further investigation of the possible role of the HPG axis in disorders that are associated with HPA axis dysfunctions. (C) 2007 Elsevier Ltd. All rights reserved.