Nicotine enhances intracellular nicotinic receptor maturation: A novel mechanism of neural plasticity?
Nicotine enhances intracellular nicotinic receptor maturation: A novel mechanism of neural plasticity?
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DOI：
10.1016/j.jphysparis.2005.12.012
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发表时间：
2006-03-01
影响因子：
--
通讯作者：
Changeux, JP
中科院分区：
文献类型：
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作者：
Corringer, PJ;Sallette, J;Changeux, JP
尼古丁成瘾是烟草消费的主要原因，通过尼古丁与脑烟碱乙酰胆碱受体（nAChRs）的结合来介导。在慢性暴露后，尼古丁引发一系列事件，从nAChR激活和脱敏开始，随后是长期上调，对应于高亲和力nAChR数量的增加，这是吸烟者大脑中发生的一个矛盾过程。最近对主要脑α 4 β 2 nAChR的成熟和运输的研究表明，在蛋白质翻译后不久，在内质网中启动上调。迄今为止积累的数据提供的证据表明，尼古丁通过促进nAChR前体的成熟来促进上调，否则这些前体将被降解。尼古丁的这种促进成熟的作用可能有助于长期尼古丁的长期作用。并提出了一种通过在生理条件下调节受体表达的未知内源性物质的神经元可塑性的新机制。(c)2006爱思唯尔有限公司保留所有权利。
Nicotine addiction, the primary cause of tobacco consumption, is mediated through nicotine binding to brain nicotinic acetylcholine receptor (nAChRs). Upon chronic exposure, nicotine elicits a cascade of events, starting with nAChR activation and desensitization, followed by a long term up-regulation that corresponds to an increase in the number of the high affinity nAChRs, a paradoxical process that occurs in the brain of smokers. Recent investigation of the maturation and trafficking of the major brain alpha 4 beta 2 nAChR demonstrates that up-regulation is initiated in the endoplasmic reticulum soon after protein translation. The data thus far accumulated provide evidence that nicotine elicits up-regulation by promoting maturation of nAChR precursors that would otherwise be degraded. This maturational enhancer" action of nicotine probably contributes to the long term effect of chronic nicotine.. and suggests a novel mechanism of neuronal plasticity through an yet unknown endogenous substance which would modulate the receptor expression under physiological conditions. (c) 2006 Elsevier Ltd. All rights reserved.