The BAG2 protein stabilises PINK1 by decreasing its ubiquitination
The BAG2 protein stabilises PINK1 by decreasing its ubiquitination
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BAG2 蛋白通过减少 PINK1 的泛素化来稳定 PINK1
DOI：
10.1016/j.bbrc.2013.10.086
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发表时间：
2013-11-15
影响因子：
3.1
通讯作者：
Guo, Jifeng
中科院分区：
文献类型：
--
作者：
Che, Xiangqian;Tang, Beisha;Guo, Jifeng
PTEN诱导的推定蛋白1(PINK1)基因突变会导致帕金森病(PD)的常染色体隐性遗传。到目前为止，关于什么可以调节PINK1的泛素蛋白酶体途径还知之甚少。在这里，我们报告了Bag2(Bcl2相关的基因家族蛋白2)，它是BAG家族的成员，它直接与PINK1结合并通过减少其泛素化来稳定PINK1。此外，我们还发现，Bag2还与致病的R492X PINK1突变直接和更紧密地结合。此外，Bag2通过比野生型物种更大程度地减少R492X PINK1的泛素化来稳定R492X PINK1突变。我们的数据首次将bag2与PINK1联系起来，加强了bag2在帕金森病相关神经退行性变中的重要作用。(C)2013 Elsevier Inc.保留所有权利。
Mutations in the PTEN-induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). Thus far, little is known about what can regulate the ubiquitin proteasome pathway of PINK1. Here, we report BAG2 (Bcl-2-associated athanogene family protein 2), a member of the BAG family, which directly binds with and stabilises PINK1 by decreasing its ubiquitination. Moreover, we found that BAG2 also binds with the pathogenic R492X PINK1 mutation directly and more tightly. Moreover, BAG2 stabilises the R492X PINK1 mutation by decreasing its ubiquitination to a greater extent than the wild-type species. Our data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in PD-related neurodegeneration. (C) 2013 Elsevier Inc. All rights reserved.