NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
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DOI：
10.1186/1740-3391-7-5
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发表时间：
2009-05-26
影响因子：
--
通讯作者：
Partonen T
中科院分区：
文献类型：
--
作者：
Englund A;Kovanen L;Saarikoski ST;Haukka J;Reunanen A;Aromaa A;Lönnqvist J;Partonen T
哺乳动物的生物钟控制着多种生理事件。主要的生物钟也会产生行为的季节性变化。季节性增加了代谢综合征的风险，有证据表明，时钟机制的破坏可能导致新陈代谢的改变。我们的目的是分析生物钟多态性是否有助于行为的季节性变化和代谢综合征。我们对来自全国范围内人群样本的517名个体的19个基因进行了39个单核苷酸多态性（SNP）的基因分型，这些基因要么是典型的生物钟基因，要么是与生物钟相关的基因。采用回归分析方法分析这些SNPs与季节性、代谢综合征及其危险因素的关系。校正了多重检验的p值。我们的发现将昼夜节律基因变异与代谢综合征的危险因素联系起来，因为Npas2与高血压相关（多重检验校正的P值= 0.0024），Per2与高空腹血糖相关（多重检验校正的P值= 0.049）。我们的研究结果支持了生物钟和代谢综合征之间存在相关关系的观点。
Mammalian circadian clocks control multiple physiological events. The principal circadian clock generates seasonal variations in behavior as well. Seasonality elevates the risk for metabolic syndrome, and evidence suggests that disruption of the clockwork can lead to alterations in metabolism. Our aim was to analyze whether circadian clock polymorphisms contribute to seasonal variations in behavior and to the metabolic syndrome. We genotyped 39 single-nucleotide polymorphisms (SNP) from 19 genes which were either canonical circadian clock genes or genes related to the circadian clockwork from 517 individuals drawn from a nationwide population-based sample. Associations between these SNPs and seasonality, metabolic syndrome and its risk factors were analyzed using regression analysis. The p-values were corrected for multiple testing. Our findings link circadian gene variants to the risk factors of the metabolic syndrome, since Npas2 was associated with hypertension (P-value corrected for multiple testing = 0.0024) and Per2 was associated with high fasting blood glucose (P-value corrected for multiple testing = 0.049). Our findings support the view that relevant relationships between circadian clocks and the metabolic syndrome in humans exist.