β2-glycoprotein 1 as a marker of antiphospholipid syndrome in women with recurrent pregnancy loss
β2-glycoprotein 1 as a marker of antiphospholipid syndrome in women with recurrent pregnancy loss
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DOI：
10.1016/s0015-0282(99)00573-7
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发表时间：
2000-03-01
影响因子：
6.7
通讯作者：
Kutteh, WH
中科院分区：
文献类型：
--
作者：
Franklin, RD;Hollier, N;Kutteh, WH
目的：为了确定β 2-糖蛋白1（β 2-GP 1）抗体是否是一个更好的标记物的抗磷脂抗体综合征（APS）的妇女反复妊娠丢失（RPL）设计：评估和测试的血清与RPL的妇女。设定：一所大学附属的生殖内分泌实践。患者：90名RPL女性; 45名女性符合APS标准，45名女性符合RPL标准，无抗磷脂抗体（阿帕）。两组年龄相似，有相似的RPL病史。干预：从患有RPL的妇女中获得患者血清，并检测阿帕和β 2-GP 1。主要结果测量：采用标准抗磷脂抗体测定来检测血清中抗心磷脂、磷脂酰肌醇、磷脂酰甘油、磷脂酰丝氨酸、磷脂酰丝氨酸、磷脂酰肌醇、磷脂酰肌醇和磷脂酰肌醇的免疫球蛋白（IG）G、IgM和伊加抗体的存在。和磷脂酰乙醇胺。结果：45例APS患者中，10例（22.2%）β 2-GP 1 IgG抗体阳性。在阿帕阴性的RPL妇女对照组中，45名妇女中只有1名（2.2%）β 2-GP 1阳性。没有相关性β 2-GP 1阳性患者之间的特定磷脂抗体或isotype. Conclusions（S）：这些数据表明，IgG β 2-GP 1抗体的敏感性低于抗磷脂抗体诊断APS。(C)2000年，美国生殖医学会。
Objective: To determine if beta 2-glycoprotein 1 (beta 2-GP1) antibodies are a better marker of the antiphospholipid antibody syndrome (APS) in women with recurrent pregnancy loss (RPL).Design: Evaluation and testing of sera from women with RPL. Setting: A university-affiliated reproductive endocrinology practice.Patient(s): 90 women with RPL; 45 women met criteria for APS and 45 women met criteria for RPL without antiphospholipid antibodies (APA). Both groups were of similar age and had a similar history of RPL.Intervention(s): Patient sera were obtained from women with RPL and were tested for APA and beta 2-GP1.Main Outcome Measure(s): A standard antiphospholipid antibody assay was employed to detect the presence of immunoglobulin (Ig)G, IgM, and IgA antibodies in serum against cardiolipin, phosphatidyl inositol, phosphatidyl glycerol, phosphatidyl serine, and phosphatidyl ethanolamine. Samples were also assayed with a commercial beta 2-GP1 assay for IgG antibodies.Result(s): Among the 45 women with APS, 10 (22.2%) had positive IgG antibodies for beta 2-GP1. Only 1 woman (2.2%) of 45 was positive for beta 2-GP1 among the control group of women with RPL but negative APA. There was no correlation noted among the beta 2-GP1-positive patients for a specific phospholipid antibody or isotype.Conclusion(s): These data suggest that IgG beta 2-GP1 antibodies are less sensitive than antiphospholipid antibodies for the diagnosis of APS. (C) 2000 by American Society for Reproductive Medicine.