Pesticide exposure and risk of breast cancer: a nested case-control study of residentially stable women living on Long Island
Pesticide exposure and risk of breast cancer: a nested case-control study of residentially stable women living on Long Island
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DOI：
10.1016/j.envres.2003.08.001
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发表时间：
2004-02-01
影响因子：
8.3
通讯作者：
Brasure, J
中科院分区：
文献类型：
--
作者：
O'Leary, ES;Vena, JE;Brasure, J
我们对居住在长岛的纽约州队列中的妇女进行了巢式病例对照研究。我们估计了1980年至1992年期间诊断为乳腺癌的105名妇女和210名年龄和种族匹配的对照组中长期居住稳定的妇女在1980年完成了一份简短的邮寄问卷调查的农药的历史环境暴露。以前的农业用地是根据1947年和1950年拍摄的航空照片进行评估的。根据1977年至1992年期间采取的措施，对饮用水中检测到的农药进行了估计。地理信息系统软件被用来计算住宅与含有农药的危险废物场之间的距离。我们发现，在调整其他风险因素后，居住在含有有机氯农药的HWS 1英里范围内的女性患乳腺癌的风险增加（比值比[OR] = 2.8; 95%置信区间[CI]，1.1-7.1）。与居住在以前用于农业的土地上的妇女相比，居住在以前用于农业的土地上的妇女和未生育过或第一次生育年龄较大（大于或等于26岁）的妇女之间存在显着的相互作用。年龄较小（
We conducted a nested case-control study of women in the New York State cohort who lived on Long Island. We estimated the historical environmental exposure to pesticides in 105 women diagnosed with breast cancer between 1980 and 1992 and 210 age and race-matched controls in this cohort of long-term residentially stable women who completed a short mailed questionnaire in 1980. Prior agricultural land use was assessed from aerial photographs taken in 1947 and 1950. Pesticides detected in drinking water were estimated from measures taken between 1977 and 1992. Geographic information system software was used to calculate the distance between residences and hazardous waste sites (HWS) containing pesticides. We found an increased breast cancer risk for women residing within I mile of HWS containing organochlorine pesticides (odds' ratio [OR] = 2.8; 95% confidence interval [CI], 1.1-7.1), after adjusting for other risk factors. A significant interaction was shown for women residing on land that was previously used for agriculture and women who were either nulliparous or had an older age at first birth (greater than or equal to26 yr old), compared to women who did not live on previously agricultural land and with a younger age (