Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?
Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?
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DOI：
10.1097/01.anes.0000281893.39781.64
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发表时间：
2007-10-01
期刊：
影响因子：
8.8
通讯作者：
Ackerman, Michael J.
中科院分区：
文献类型：
--
作者：
Nuttall, Gregoty A.;Eckerman, Karen M.;Ackerman, Michael J.
背景资料：美国食品和药物管理局发布了一个黑盒警告有关使用氟哌利多和尖端扭转型室性心动过速（TdP）的可能性：本回顾性研究的主要目的是确定是否低剂量氟哌利多管理增加TdP的发生率在普通外科人群在3年的时间内之前和之后的食品和药物管理局黑盒警告。在每个时间间隔随机抽取150例手术患者，以估计氟哌利多的使用为每个时间periods.Results：在黑盒警告之前的时间段（1998年7月1日至2001年6月30日），2,321/139,932例（1.66%）有QT间期延长，TdP，或手术后48小时内死亡。在黑盒警告之前，我们无法识别出明确发展为TdP的患者。有1例患者的死亡原因不能明确排除为TdP所致。在黑框警告后的时间段内（2002年7月1日至2005年6月30日），2,207例患者（1.46%）在术后48小时内记录到QT间期延长、TdP或死亡，其中仅2例（
Background: The US Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes (TdP).Methods: The primary objective of this retrospective study was to determine whether low-dose droperidol administration increased the incidence of TdP in the general surgical population during a 3-yr time period before and after the Food and Drug Administration black box warning. A random sample of 150 surgical patients during each time interval was selected to estimate the droperidol use for each time period.Results: During the time period before the black box warning (July 1, 1998 to June 30, 2001), 2,321/139,932 patients (1.66%) had QT prolongation, TdP, or death within 48 h after surgery. we could identify no patients who clearly developed TdP before the black box warning. There was one patient for whom the cause of death could not positively be ruled out as due to TdP. In the time period after the black box warning (July 1, 2002 to June 30, 2005), 2,207 patients (1.46%) had documented QT prolongation, TdP, or death within 48 h after surgery, including only two cases (