CRISPR babies: a view from the centre of the storm
CRISPR babies: a view from the centre of the storm
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CRISPR 婴儿：风暴中心的视角
DOI：
10.1242/dev.175778
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发表时间：
2019
期刊：
影响因子：
4.6
通讯作者：
R. Lovell
中科院分区：
文献类型：
--
作者：
R. Lovell
摘要2018年11月底，有消息称，中国研究人员贺建奎创造了世界上第一个基因组编辑的婴儿。这是在第二届人类基因组编辑国际峰会开始前不久，来自世界各地的研究人员，伦理学家和其他关注监管，社会问题和公众参与的人聚集在一起，讨论该领域的最新进展。在这篇重点报道中，我提供了我对峰会前不久和峰会期间发生的事件的看法，贺建奎在峰会上介绍了他的活动。我还讨论了他的方法有什么问题，以及在更多的研究和适当的监管之后，人类生殖系基因组编辑的临床应用可能是合理的。总结：Robin Lovell-Badge对Jiankui He最近关于世界上第一个基因组编辑婴儿的报告给出了他的观点，并讨论了生殖系基因组编辑在人类中的临床应用是否以及如何合理。
ABSTRACT Towards the end of November 2018, news broke that the Chinese researcher He Jiankui had created the world's first genome-edited babies. This came shortly before the start of the Second International Summit on Human Genome Editing, where researchers, ethicists and others concerned with regulation, social issues and public engagement from around the world gathered to discuss the latest advances in the field. In this Spotlight, I provide my perspective on the events that occurred shortly prior to and at the summit, where He Jiankui gave an account of his activities. I also discuss what was wrong with his approach and how, after more research and with appropriate regulation, clinical applications of germline genome editing in humans may be justifiable. Summary: Robin Lovell-Badge gives his perspective on the recent report from Jiankui He of the world's first genome edited babies and discusses if and how clinical applications of germline genome editing in humans may be justifiable.
CCR5 32 bp 缺失等位基因在中国人群中很少见。
影响因子：
4.5
作者：
Wang,Fan;Xiu,MeiHong;Zhou,DongFeng;Cao,LianYuan;Wu,GuiYing;Kosten,ThereseA;Kosten,ThomasR;Zhang,XiangYang
通讯作者：
Zhang,XiangYang