Knee cartilage topography, thickness, and contact areas from MRI: in-vitro calibration and in-vivo measurements
Knee cartilage topography, thickness, and contact areas from MRI: in-vitro calibration and in-vivo measurements
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DOI：
10.1053/joca.1998.0165
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发表时间：
1999-01-01
影响因子：
7
通讯作者：
Ateshian, GA
中科院分区：
文献类型：
--
作者：
Cohen, ZA;McCarthy, DM;Ateshian, GA
目的：本研究通过与校准立体摄影测量（SPG）方法的比较，评估了磁共振成像（MRI）测量人类尸体膝关节关节表面形貌和软骨厚度的三维准确性。方法：对6个新鲜冷冻尸体膝关节和4个志愿者膝关节进行三维破坏梯度成像，在1.5 T超导磁体中使用线性末端线圈进行脂肪抑制的召回采集。成像体素大小为0.47 x 0.47 x 1.0 mm。采用手动和半自动分割方法从MRI中提取地形测量值。MRI后，解剖6个尸体膝关节，并使用立体摄影测量法对其关节面进行定量。将MRI表面测量值与SPG测量值进行数值比较。对于6个尸体膝关节，软骨和软骨下骨表面测量的平均精度分别为0.22 mm和0.14 mm，厚度测量的平均精度为0.31 mm。系统误差对精度有一定影响。对于膝盖的每块骨头，髌骨的准确度最有利，其次是股骨，然后是胫骨。更有效的半自动化方法提供了同样好的，有时更好的精度比手动segmentation.Conclusions：这项研究表明，临床MRI可以提供准确的测量软骨地形，厚度，接触面积和表面曲率的膝盖。
Objective: This study assessed the three-dimensional accuracy of magnetic resonance imaging (MRI) for measuring articular surface topographies and cartilage thicknesses of human cadaveric knee joints, by comparison with the calibrated stereophotogrammetric (SPG) method.Methods: Six fresh frozen cadaveric knees and the knees of four volunteers were imaged with a three-dimensional spoiled gradient-recalled acquisition with fat suppression using a linear extremity coil in a 1.5 T superconducting magnet. The imaging voxel size was 0.47 x 0.47 x 1.0 mm. Both a manual and a semi-automated segmentation method were employed to extract topographic measurements from MRI. Following MRI, each of the six cadaveric knees was dissected and its articular surfaces quantified using stereophotogrammetry. The MRI surface measurements were compared numerically with the SPG; measurements.Results: For six cadaveric knees, the average accuracies of cartilage and subchondral bone surface measurements were found to be 0.22 mm and 0.14 mm respectively and the thickness measurements demonstrated an average accuracy of 0.31 mm. It was found that while most of the error may be attributed to random measurement error, the accuracy was somewhat affected by systematic errors. For each bone of the knee, accuracies were most favorable in the patella, followed by the femur and then the tibia. The more efficient semi-automated method provided equally good and sometimes better accuracies than manual segmentation.Conclusions: This study demonstrates that clinical MRI can provide accurate measurements of cartilage topography, thickness, contact areas and surface curvatures of the knee.