Validity of retinal oxygen saturation analysis: Hyperspectral imaging in visible wavelength with fundus camera and liquid crystal wavelength tunable filter
Validity of retinal oxygen saturation analysis: Hyperspectral imaging in visible wavelength with fundus camera and liquid crystal wavelength tunable filter
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DOI：
10.1007/bf02919416
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发表时间：
2007-05-01
期刊：
影响因子：
1.2
通讯作者：
Fujikado, Takashi
中科院分区：
文献类型：
--
作者：
Hirohara, Yoko;Okawa, Yoshitaka;Fujikado, Takashi
本文的目的是探讨一种新开发的高光谱眼底成像相机与液晶可调滤波器的可行性。测量了不同波长的光通过动脉、静脉及其周围区域并反射出去的强度，并分析了差分光谱吸收。测量了16只正常眼和两个人工毛细血管。计算动脉与静脉在500 ~ 580 nm（范围1）和600 ~ 720 nm（范围2）的吸收比（罗阿）。所有患眼的罗阿（范围1）均大于罗阿（范围2）。用充氧或充氮血液的人工毛细血管获得的罗阿与氧合和脱氧血红蛋白消光率的模拟数据相似。人眼的ROA大多数低于模拟数据和人工毛细血管的ROA。通过视网膜血管的高光谱眼底成像的氧饱和度分析与体外分析或模拟值定性一致。然而，进一步的改进是必要的，以定量评估在视网膜血管中的氧饱和度。(c)2007年日本光学学会
The purpose of this paper was to investigate the feasibility of a newly developed hyperspectral fundus imaging camera with a liquid crystal tunable filter. The intensities of different wavelengths of light transmitted through an artery, vein, and the area surrounding these vessels and reflected out were measured, and the differential spectral absorptions were analyzed. Measurements were made from 16 normal eyes and from two artificial capillaries. The ratios of absorption (ROA) of arteries to veins from 500 to 5 80 nm (range 1) and from 600 to 720 nm (range 2) were calculated. For all eyes, the ROA(range1) was larger than ROA(range2). The ROA obtained from the artificial capillary filled with blood saturated with oxygen or nitrogen was similar to that of simulated data of oxy- and deoxyhemoglobin extinction rate. Most ROAs of human eyes were lower than those of the simulated data and the artificial capillaries. Oxygen saturation analysis by hyperspectral fundus imaging of retinal vessels were qualitatively in agreement with the in vitro analysis or simulated values. However, further improvements are necessary to evaluate the oxygen saturation quantitatively in the retinal blood vessels. (c) 2007 The Optical Society of Japan