Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs.
Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs.
复制标题
新型 1-甲基-4-苯基-1,2,3,6-四氢吡啶类似物抑制二氢蝶啶还原酶。
DOI：
10.1126/science.6608790
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Brossi,A
中科院分区：
文献类型：
--
作者：
Abell,CW;Shen,RS;Gessner,W;Brossi,A
Hydroxylated derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a nigrostriatal neurotoxin in humans and primates, noncompetitively inhibited dihydropteridine reductase from human liver and rat striatal synaptosomes in vitro at micromolar concentrations. In contrast, MPTP and its chloro- and norderivatives did not inhibit this enzyme at lower than millimolar concentrations. Dihydropteridine reductase converts dihydrobiopterin to tetrahydrobiopterin, the required cofactor for the hydroxylation of aromatic amino acids during the synthesis of dopamine and serotonin.
