Osteophytes and joint space narrowing are independently associated with pain in finger joints in hand osteoarthritis
Osteophytes and joint space narrowing are independently associated with pain in finger joints in hand osteoarthritis
复制标题
DOI：
10.1136/ard.2010.147553
复制
发表时间：
2011-10-01
影响因子：
27.4
通讯作者：
Kloppenburg, Margreet
中科院分区：
文献类型：
--
作者：
Kortekaas, Marion C.;Kwok, Wing-Yee;Kloppenburg, Margreet
目的探讨手部骨关节炎（HOA）患者的超声（US）和常规X线（CR）检查结果与疼痛的关系（平均年龄61岁，86%为女性）符合美国流变学学会标准，通过触诊评估30个单独手关节的疼痛;通过US和CR评估骨赘，通过CR评估关节间隙狭窄（JSN）。结构异常和疼痛之间的关联，每个关节进行了分析，使用广义估计方程，占患者的影响，并调整年龄，性别，体重指数，美国炎症功能和其他剩余的结构abnormality.Results在1649关节，69%和46%的骨赘在美国和CR，分别和47%的JSN。骨赘和JSN显示出与调整后的每个关节疼痛的独立相关性：骨赘的OR：US为4.8（95%CI 3.1至7.5），CR为4.1（95%CI 2.4至7.1）; JSN为4.2（95%CI 2.0至9.0）。
Objective To study the associations between structural abnormalities on ultrasound (US) or conventional x-rays (CR) and pain in hand osteoarthritis (HOA).Methods In 55 consecutive patients with HOA (mean age 61 years, 86% women) fulfilling the American College of Rheumatology criteria, pain in 30 separate hand joints was assessed upon palpation; osteophytes were assessed by US and CR and joint space narrowing (JSN) by CR. Associations between structural abnormalities and pain per joint were analysed using generalised estimated equations to account for patient effects and adjusted for age, sex, body mass index, US inflammatory features and other remaining structural abnormalities.Results In 1649 joints, 69% and 46% had osteophytes on US and CR, respectively and 47% had JSN. Osteophytes and JSN showed independent associations with pain per joint adjusted: OR for osteophytes: 4.8 (95% CI 3.1 to 7.5) for US and 4.1 (95% CI 2.4 to 7.1) for CR; for JSN: 4.2 (95% CI 2.0 to 9.0).Conclusions Osteophytes and JSN are independently associated with pain in individual HOA joints, taking into account patient effects.