PROTECTION AGAINST COGNITIVE IMPAIRMENT AND MODIFICATION OF EPILEPTOGENESIS WITH CURCUMIN IN A POST-STATUS EPILEPTICUS MODEL OF TEMPORAL LOBE EPILEPSY
PROTECTION AGAINST COGNITIVE IMPAIRMENT AND MODIFICATION OF EPILEPTOGENESIS WITH CURCUMIN IN A POST-STATUS EPILEPTICUS MODEL OF TEMPORAL LOBE EPILEPSY
复制标题
姜黄素在颞叶癫痫持续状态模型中预防认知障碍和改变癫痫发生
DOI：
10.1016/j.neuroscience.2015.09.058
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发表时间：
2015-12-03
期刊：
影响因子：
3.3
通讯作者：
Lin, Z.
中科院分区：
文献类型：
--
作者：
Jiang, Z.;Guo, M.;Lin, Z.
癫痫发生是一个动态过程，由脑损伤引发，其特征是某些脑区的进行性功能和结构改变，导致自发性复发性癫痫发作的出现。在脑创伤和自发性复发性癫痫发作出现的持续时间内，通常存在潜伏期，这可能为预防癫痫发作提供治疗窗口。先前的动物研究表明，姜黄素可以减轻急性癫痫发作的严重程度和脑氧化应激，但姜黄素对癫痫发生的影响尚未研究。我们研究了在潜伏期持续给予姜黄素对癫痫发生的影响，以及在海人酸诱导的颞叶癫痫的癫痫持续状态后模型中成年大鼠癫痫持续状态的有害后果。我们证明，虽然在潜伏期给予姜黄素治疗并不能阻止癫痫持续状态后自发性复发性癫痫发作的发生，但它可以减轻自发性复发性癫痫发作的严重程度并防止认知障碍。因此，在癫痫持续状态后的潜伏期内用姜黄素治疗有利于改变癫痫发生。(C)2015年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Epileptogenesis is a dynamic process initiated by insults to the brain that is characterized by progressive functional and structural alterations in certain cerebral regions, leading to the appearance of spontaneous recurrent seizures. Within the duration of the trauma to the brain and the appearance of spontaneous recurrent seizures, there is typically a latent period, which may offer a therapeutic window for preventing the emergence of epilepsy. Previous animal studies have shown that curcumin can attenuate acute seizure severity and brain oxidative stress, but the effect of curcumin on epileptogenesis has not been studied. We examined the effect of continued administration of curcumin during the latent period on epileptogenesis and the deleterious consequences of status epilepticus in adult rats in a post-status epilepticus model of temporal lobe epilepsy induced by kainic acid. We demonstrate that, while administration of curcumin treatment during the latent period does not prevent occurrence of spontaneous recurrent seizures after status epilepticus, it can attenuate the severity of spontaneous recurrent seizures and protect against cognitive impairment. Thus, treatment with curcumin during the latent period following status epilepticus is beneficial in modifying epileptogenesis. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.