Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
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DOI：
10.1093/annonc/mdt303
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Panel members
中科院分区：
文献类型：
--
作者：
Goldhirsch A;Winer EP;Coates AS;Gelber RD;Piccart-Gebhart M;Thürlimann B;Senn HJ;Panel members
第13届圣加仑国际乳腺癌会议（2013年）专家小组审查并认可了早期乳腺癌局部和区域治疗方面的大量新证据，支持腋窝手术范围较小和放射治疗持续时间较短。它完善了其早期的方法来分类和管理管腔疾病的扩增或过度表达的人表皮生长因子受体2（HER2）癌基因的情况下，同时保留基本不变的建议，全身辅助治疗HER2阳性和“三阴性”疾病。专家组再次接受传统的临床病理因素提供了替代亚型分类，同时注意到在世界上那些多基因分子测定容易获得的地区，许多临床医生更喜欢根据这些基因组结果而不是替代亚型定义来决定管腔疾病患者的化疗。几种多基因分子检测被认为是提供准确和可重复的预后信息，并在某些情况下预测对化疗的反应。目前，成本和可用性阻碍了它们在许多环境中的应用。提出了广泛的治疗建议。这些建议并不意味着每个小组成员都同意：事实上，在100多个问题中，只有一个（曲妥珠单抗持续时间）要求100%同意。事实上，不同的建议得到了不同程度的支持，这反映在下面文本的微妙措辞和补充附录S1中记录的投票中，可在Annals of Oncology在线查阅。治疗的详细决定将一如既往地涉及对疾病程度、宿主因素、患者偏好以及社会和经济限制的临床考虑。
The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local and regional therapies for early breast cancer, supporting less extensive surgery to the axilla and shorter durations of radiation therapy. It refined its earlier approach to the classification and management of luminal disease in the absence of amplification or overexpression of the Human Epidermal growth factor Receptor 2 (HER2) oncogene, while retaining essentially unchanged recommendations for the systemic adjuvant therapy of HER2-positive and ‘triple-negative’ disease. The Panel again accepted that conventional clinico-pathological factors provided a surrogate subtype classification, while noting that in those areas of the world where multi-gene molecular assays are readily available many clinicians prefer to base chemotherapy decisions for patients with luminal disease on these genomic results rather than the surrogate subtype definitions. Several multi-gene molecular assays were recognized as providing accurate and reproducible prognostic information, and in some cases prediction of response to chemotherapy. Cost and availability preclude their application in many environments at the present time. Broad treatment recommendations are presented. Such recommendations do not imply that each Panel member agrees: indeed, among more than 100 questions, only one (trastuzumab duration) commanded 100% agreement. The various recommendations in fact carried differing degrees of support, as reflected in the nuanced wording of the text below and in the votes recorded in supplementary Appendix S1, available at Annals of Oncology online. Detailed decisions on treatment will as always involve clinical consideration of disease extent, host factors, patient preferences and social and economic constraints.
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影响因子：
168.9
作者：
Davies, Christina;Pan, Hongchao;Godwin, Jon;Gray, Richard;Arriagada, Rodrigo;Raina, Vinod;Abraham, Mirta;Medeiros Alencar, Victor Hugo;Badran, Atef;Bonfill, Xavier;Bradbury, Joan;Clarke, Michael;Collins, Rory;Davis, Susan R.;Delmestri, Antonella;Forbes, John F.;Haddad, Peiman;Hou, Ming-Feng;Inbar, Moshe;Khaled, Hussein;Kielanowska, Joanna;Kwan, Wing-Hong;Mathew, Beela S.;Mittra, Indraneel;Mueller, Bettina;Nicolucci, Antonio;Peralta, Octavio;Pernas, Fany;Petruzelka, Lubos;Pienkowski, Tadeusz;Radhika, Ramachandran;Rajan, Balakrishnan;Rubach, Maryna T.;Tort, Sera;Urrutia, Gerard;Valentini, Miriam;Wang, Yaochen;Peto, Richard
通讯作者：
Peto, Richard
影响因子：
158.5
作者：
Coleman, Robert E.;Marshall, Helen;Bell, Richard
通讯作者：
Bell, Richard
影响因子：
6.4
作者：
Buckland, G.;Travier, N.;Riboli, E.
通讯作者：
Riboli, E.
DOI：
10.1073/pnas.1018858109
发表时间：
2012-10-30
影响因子：
11.1
作者：
Bailey, Shannon T.;Shin, Hyunjin;Brown, Myles
通讯作者：
Brown, Myles
影响因子：
168.9
作者：
Albain, K.;Anderson, S.;Arriagada, R.;Barlow, W.;Bergh, J.;Bliss, J.;Buyse, M.;Cameron, D.;Carrasco, E.;Clarke, M.;Correa, C.;Coates, A.;Collins, R.;Costantino, J.;Cutter, D.;Cuzick, J.;Darby, S.;Davidson, N.;Davies, C.;Davies, K.;Delmestri, A.;Di Leo, A.;Dowsett, M.;Elphinstone, P.;Evans, V.;Ewertz, M.;Gelber, R.;Gettins, L.;Geyer, C.;Goldhirsch, A.;Godwin, J.;Gray, R.;Gregory, C.;Hayes, D.;Hill, C.;Ingle, J.;Jakesz, R.;James, S.;Kaufmann, M.;Kerr, A.;MacKinnon, E.;McGale, P.;McHugh, T.;Norton, L.;Ohashi, Y.;Paik, S.;Pan, H. C.;Perez, E.;Peto, R.;Piccart, M.;Pierce, L.;Pritchard, K.;Pruneri, G.;Raina, V.;Ravdin, P.;Robertson, J.;Rutgers, E.;Shao, Y. F.;Swain, S.;Taylor, C.;Valagussa, P.;Viale, G.;Whelan, T.;Winer, E.;Wang, Y.;Wood, W.
通讯作者：
Wood, W.