The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations
The association of functional polymorphisms in the aryl hydrocarbon receptor (AHR) gene with the risk of vitiligo in Han Chinese populations
复制标题
芳烃受体（AHR）基因功能多态性与中国汉族人群白癜风风险的关系
DOI：
10.1111/j.1365-2133.2011.10798.x
复制
发表时间：
2012-05-01
影响因子：
10.3
通讯作者：
Gao, T-W.
中科院分区：
文献类型：
--
作者：
Wang, X-W.;Li, K.;Gao, T-W.
背景：白癜风是一种获得性色素脱失疾病，其原因是选择性破坏黑素细胞。芳香烃受体(AHR)通过调节黑素生成相关基因的表达，对黑素生成和黑素细胞的增殖分化起着重要的调节作用。AHR突变可能对AHR蛋白及其靶基因产生负面影响。目的探讨AHR基因多态性与白癜风易感性之间的关系。方法对1000例白癜风患者和1000例年龄、性别匹配的非白癜风患者进行病例对照研究。结果发现rs10249788的TT和CT基因型[优势比(OR)0.59，95%可信区间(CI)0.38~0.93；P=0.028和OR0.82，95%CI 0.68~0.98；P=0.032]与白癜风发病风险显著相关
Background Vitiligo is an acquired depigmentation disorder resulting from selective destruction of melanocytes. The aryl hydrocarbon receptor (AHR) is vital to the regulation of melanogenesis and melanocyte proliferation and differentiation through modulating the expressions of melanogenesis-related genes. AHR mutations may negatively affect AHR proteins and its target genes. Therefore, we hypothesized that AHR polymorphisms might be involved in vitiligo by impacting the transcriptional activities of related genes as mentioned above.Objectives To evaluate the potential association between AHR polymorphisms and vitiligo susceptibility.Methods We performed a hospital-based, case-control study of 1000 patients with vitiligo and 1000 vitiligo-free but age-and gender-matched controls. Two single nucleotide polymorphisms of the AHR gene (rs10249788 and rs2066853) were selected and genotyped using a polymerase chain reaction-restriction fragment length polymorphism method.Results A statistically significantly decreased risk of vitiligo was found to be associated with the TT and CT genotypes of rs10249788 [odds ratio (OR) 0 59, 95% confidence interval (CI) 0.38-0.93; P = 0.028 and OR 0.82, 95% CI 0.68-0.98; P = 0 032, respectively] as well as among subgroups: male, active, nonsegmental vitiligo, and onset age