Development of functionalized hollow microporous organic capsules encapsulating morphine - an in vitro and in vivo study
Development of functionalized hollow microporous organic capsules encapsulating morphine - an in vitro and in vivo study
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封装吗啡的功能化中空微孔有机胶囊的开发——体外和体内研究
DOI：
10.1039/c6tb02497a
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发表时间：
2017
影响因子：
7
通讯作者：
Tan Bien
中科院分区：
文献类型：
--
作者：
Razzaque Shumaila;Cai Chen;Lu Qun Wei;Huang Feng Zhen;Li Yu Sang;Tang He Bin;Hussain Irshad;Tan Bien
具有中空内壁的微孔有机胶囊由于其不同寻常的封装效率而受到极大的关注，这些胶囊可以将化学物质限制在中空空腔内，并通过避免它们的成熟或中毒来促进控制释放。为此，我们报道了一种简单的乳液聚合技术，设计并合成了羧基功能化中空微孔有机胶囊(HMOCs)，该胶囊显示出极高的吗啡·盐酸盐包封率(高达98%)和良好的缓释前景。功能化的HMOCs被发现以与其内部残留的药物量成正比的速度释放药物。由于存在中空和多孔的形态，它们具有高的比表面积，即高达974m2g−1。此外，体内实验结果表明，功能化的HMOCs可以提供活性药物分子的缓慢释放，并在72h内减弱扭体反应。因此，功能化的HMOCs提供了一类新的潜在的药物释放系统，可以通过降低剂量和避免频繁给药来维持止痛剂的缓慢和长期释放。
Microporous organic capsules with hollow interiors have received enormous attention due to their unusual encapsulation efficiency to confine chemicals within their hollow cavities and prompted controlled release by circumventing their ripening or poisoning. To this end, herein, we report the design and synthesis of carboxylic group functionalized hollow microporous organic capsules (HMOCs) using a facile emulsion polymerization technique that show extraordinary high encapsulation efficiency (up to 98%) of morphine·HCl and its promising prolonged release. The functionalized HMOCs are found to release the drug at a rate which is proportional to the amount of drug remaining in its interior. Due to the presence of hollow and porous morphologies, they possess high BET surface areas, i.e. up to 974 m2 g−1. Moreover, the in vivo results showed that functionalized HMOCs can offer slow release of active drug molecules and attenuate the level of writhing response over 72 h of intraperitoneal injection. The functionalized HMOCs, therefore, present a new class of potential drug delivery systems that can maintain the slow and prolonged release of analgesics by lowering the dosage and avoid frequent administration.