Real-Time Pathology Through In Vivo Microscopy
Real-Time Pathology Through In Vivo Microscopy
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DOI：
10.3233/978-1-61499-234-9-235
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Contag, Christopher H.
中科院分区：
文献类型：
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作者：
Liu, Jonathan T. C.;Loewke, Nathan O.;Contag, Christopher H.
微型显微镜正在开发中，用于在原位以真实的时间和细胞分辨率检查组织，以获得疾病的早期解剖学和分子指标。这些新设备将导致从目前的活检诊断模式，然后是组织病理学和推荐的治疗，转变为一种非侵入性的床旁诊断，并有可能在同一个疗程中进行治疗。这一潜在的疾病管理革命可能对未来医生的培训产生重大影响，包括使用和解释实时体内显微镜数据，也将影响远程病理学和远程医疗等新兴领域。将新技术应用于临床实践是一个复杂的过程，需要临床医生、工程师和科学家之间进行多学科的沟通和协作。因此，我们的目标是提供新技术发展所面临的关键问题的前瞻性观点，并指导临床教育。在这里，我们专注于使用体内显微镜检测恶性和癌前病变以及指导治疗。我们将重点介绍体内显微镜可以解决未满足的临床需求的一些领域，然后回顾正在解决或需要解决的技术挑战，使体内显微镜成为一种有效的临床工具。
Miniature microscopes are being developed to examine tissue in situ for early anatomic and molecular indicators of disease, in real time, and at cellular resolution. These new devices will lead to a shift from the current diagnostic paradigm of biopsy followed by histopathology and recommended therapy, to one of non-invasive point-of-care diagnosis with the possibility of treatment in the same session. This potential revolution in disease management may have a major impact on the training of future physicians to include the use and interpretation of real-time in vivo microscopic data, and will also affect the emerging fields of telepathology and telemedicine. Implementation of new technologies into clinical practice is a complex process that requires multidisciplinary communication and collaboration among clinicians, engineers and scientists. As such, our aim is to provide a forward-looking view of the critical issues facing the development of new technologies and directing clinical education. Here, we focus on the use of in vivo microscopy for detection of malignant and pre-malignant lesions as well as for guiding therapy. We will highlight some of the areas in which in vivo microscopy could address unmet clinical needs, and then review the technological challenges that are being addressed, or need to be addressed, for in vivo microscopy to become an effective clinical tool.