Regulation of rat pineal hydroxyindole-O-methyltransferase: evidence of S-adenosylmethionine-mediated glucocorticoid control.
Regulation of rat pineal hydroxyindole-O-methyltransferase: evidence of S-adenosylmethionine-mediated glucocorticoid control.
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大鼠松果体羟基吲哚-O-甲基转移酶的调节：S-腺苷甲硫氨酸介导的糖皮质激素控制的证据。
DOI：
10.1111/j.1471-4159.1980.tb03688.x
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发表时间：
1980
影响因子：
4.7
通讯作者：
Ciaranello,RD
中科院分区：
文献类型：
--
作者：
SandrockJr,AW;Leblanc,GG;Wong,DL;Ciaranello,RD
: Rat pineal hydroxyindole‐O‐methyltransferase is controlled similarly to adrenal medullary phenylethanolamineN‐methyltransferase.S‐adenosylmethionine (SAM), thein vivocofactor utilized by the enzyme to convertN‐acetylserotonin to melatonin, protects this methyltransferase against tryptic proteolysisin vitro.Furthermore,in vivostudies suggest that the nucleoside itself is controlled by glucocorticoids. Hypophysectomy decreases hydroxyindole‐O‐methyltransferase levels as compared with control animals, while dexamethasone and SAM administration restore enzyme levels toward control values.In vitroproteolytic studies further demonstrate that, althoughN‐acetylserotonin does not stabilize the enzyme against trypsinization, this substrate acts synergistically with SAM to confer greater stabilization than observed with SAM alone.
