Regular exercise as an effective approach in antihypertensive therapy
Regular exercise as an effective approach in antihypertensive therapy
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DOI：
10.1249/01.mss.0000106173.81966.90
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发表时间：
2004-01-01
期刊：
影响因子：
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通讯作者：
Scholze, J
中科院分区：
文献类型：
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作者：
Ketelhut, RG;Franz, IW;Scholze, J
KETELHUT、R.G.、I.W.FRANZ 和 J.SCHOLZE。定期锻炼是抗高血压治疗的有效方法。医学。科学。体育锻炼，卷。 36，第 1 期，第 4-8 页，2004 年。 目的：已充分证明运动对心血管健康具有有益作用。从心血管预防的角度来看，有效控制动脉压（BP）至关重要。到目前为止，还没有研究确定定期训练作为单一疗法对静息时和运动时血压的长期影响。方法：因此，对 10 名高血压受试者（年龄 43 +/- 3 岁）进行了研究，以确定血压对长期有氧训练的反应。血压测量是在休息时和测功（50-100 W）期间获得的。指导患者每周锻炼一次（2 x 60 分钟有氧运动）。结果：经过 6 个月的常规训练后，运动期间 (100 W) 的血压确实已从 184 +/- 10/107 +/- 6 下降到 170 +/- 10/100 +/- 7，这与心率压力乘积（100 W 时）下降 14% 相关。训练 18 个月后，静息时血压从 139 +/- 9/96 6 进一步降低至 133 +/- 14/91 +/- 7 (P < 0.05)，测功 (100 W) 期间血压从 184 +/- 10/107 +/- 6 进一步降低至 172 +/- 8/96 +/- 6 mm Ha (P < 0.001）。在 3 年随访期间，血压持续显着下降，静息时血压为 130 +/- 13/87 +/- 7 mm Hg，运动时血压为 167 +/- 9/92 +/- 6 mm Hg。在训练期间没有记录到体重的显着变化。结论：数据表明，长期有氧运动与静息和运动时血压下降相关，这与药物治疗的效果相当。定期训练的这种降压效果可以维持长达3年。
KETELHUT, R. G., I. W. FRANZ, and J. SCHOLZE. Regular Exercise as an Effective Approach in Anti hypertensive Therapy. Med. Sci. Sports Exerc., Vol. 36, No. 1, pp. 4-8, 2004. Purpose: Exercise has been well documented to exert a beneficial effect on cardiovascular health. The effective control of arterial pressure (BP) is essential from the standpoint of cardiovascular prevention. So far, no study has determined the long-term effect of regular training as a monotherapy on both BP at rest and during exercise. Methods: Therefore, 10 subjects with hypertension (aged 43 +/- 3 yr) were studied in order to define BP response to long-term aerobic training. BP measurements were obtained at rest and during ergometry (50-100 W). Patients were instructed to exercise weekly (2 x 60 min aerobic exercise). Results: BP during exercise (100 W) did fall already after 6 months of regular training from 184 +/- 10/107 +/- 6 to 170 +/- 10/100 +/- 7, and this was associated with a 14% decrease in the rate-pressure product (at 100 W). After 18 months of training, there were further reductions in BP, at rest from 139 +/- 9/96 6 to 133 +/- 14/91 +/- 7 (P < 0.05) and during ergometry (100 W) from 184 +/- 10/107 +/- 6 to 172 +/- 8/96 +/- 6 mm Ha (P < 0.001). During a 3-yr follow-up, BP continued to decrease significantly to 130 +/- 13/87 +/- 7 mm Hg at rest and 167 +/- 9/92 +/- 6 mm Hg during exercise. No significant changes in body weight were documented during the training period. Conclusion: The data demonstrate that long-term aerobic exercise is associated with a decrease in BP at rest and during exercise, which is comparable to that of drug therapies. This antihypertensive effect of regular training can be maintained as long as 3 yr.