Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
Temporal delays among place cells determine the frequency of population theta oscillations in the hippocampus
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DOI：
10.1073/pnas.0912478107
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发表时间：
2010-04-27
影响因子：
11.1
通讯作者：
Buzsaki, Gyoergy
中科院分区：
文献类型：
--
作者：
Geisler, Caroline;Diba, Kamran;Buzsaki, Gyoergy
海马神经元由外部标志或内部动力驱动，形成细胞组装序列。这些活性细胞的协调放电是由局部场电位（LFP）中突出的“θ”振荡组织的：当大鼠穿过相应的位置场时，位置细胞在逐渐提前的θ相位放电（“相位进动”）。更快的振荡频率的活跃神经元和较慢的θ LFP，潜在的相位进动，创造了一个悖论。快速振荡的神经元如何构成LFP所反映的较慢的群体振荡？我们建立了一个数学模型，使我们能够计算人口活动分析从实验得出的参数的单神经元振荡频率，发射场的大小（持续时间），以及θ内延迟的位置细胞对和它们的距离表示（“压缩”）之间的关系。这些参数的适当组合产生了恒定的频率群体节奏沿着海马的隔颞轴，同时允许单个神经元改变其振荡频率和字段大小。我们的研究结果表明，快于θ振荡的锥体细胞是固有的，相位进动是协调活动的时间转移的细胞组件，相对于人口活动，反映了LFP的结果。
Driven either by external landmarks or by internal dynamics, hippocampal neurons form sequences of cell assemblies. The coordinated firing of these active cells is organized by the prominent "theta" oscillations in the local field potential (LFP): place cells discharge at progressively earlier theta phases as the rat crosses the respective place field ("phase precession"). The faster oscillation frequency of active neurons and the slower theta LFP, underlying phase precession, creates a paradox. How can faster oscillating neurons comprise a slower population oscillation, as reflected by the LFP? We built a mathematical model that allowed us to calculate the population activity analytically from experimentally derived parameters of the single neuron oscillation frequency, firing field size (duration), and the relationship between within-theta delays of place cell pairs and their distance representations ("compression"). The appropriate combination of these parameters generated a constant frequency population rhythm along the septo-temporal axis of the hippocampus, while allowing individual neurons to vary their oscillation frequency and field size. Our results suggest that the faster-than-theta oscillations of pyramidal cells are inherent and that phase precession is a result of the coordinated activity of temporally shifted cell assemblies, relative to the population activity, reflected by the LFP.