Isolation and characterization of gangliosides with a new sialosyl linkage and core structures. II. Gangliosides of human erythrocyte membranes.
Isolation and characterization of gangliosides with a new sialosyl linkage and core structures. II. Gangliosides of human erythrocyte membranes.
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具有新唾液酸基连接和核心结构的神经节苷脂的分离和表征。
DOI：
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发表时间：
1979
影响因子：
4.8
通讯作者：
S. Hakomori
中科院分区：
文献类型：
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作者：
K. Watanabe;M. Powell;S. Hakomori
从人红细胞膜中分离出八种单唾液酸神经节苷脂，G1至G8，并测定了它们的结构。神经节苷脂G4和G7的特征在于在其末端具有2个导致6-连接的唾液酸至半乳糖。神经节苷脂G5是脑神经节苷脂GM 1的唾液酸键合位置异构体。神经节苷脂G8被表征为类似于先前分离的岩藻神经节苷脂但不含岩藻糖的支链神经节苷脂，并且它显示出强的血型I活性。这四种新的神经节苷脂的结构如下所示：（分子式：见正文）。
Eight monosialosylgangliosides, G1 to G8, have been isolated from human erythrocyte membranes and their structures have been determined. Gangliosides G4 and G7 have been characterized by having 2 leads to 6-linked sialic acid to galactose at their termini. Ganglioside G5 was a positional isomer of a brain ganglioside GM1 as to the linkage of sialic acid. Ganglioside G8 was characterized as a branched chain ganglioside similar to a fucoganglioside previously isolated but devoid of fucose, and it showed a strong blood group I activity. Structures of these four new gangliosides are shown below: (formula: see text).