Nonuniform surround suppression of visual responses in mouse V1.
Nonuniform surround suppression of visual responses in mouse V1.
复制标题
小鼠 V1 视觉反应的非均匀环绕抑制。
DOI：
10.1152/jn.00172.2017
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发表时间：
2017
影响因子：
2.5
通讯作者：
Kuhlman,SandraJ
中科院分区：
文献类型：
--
作者：
Samonds,JasonM;Feese,BerquinD;Lee,TaiSing;Kuhlman,SandraJ
复杂的感受野特征，分布在一个群体的神经元，被认为是解决感知推理问题，在运动和图像分割过程中出现的关键。例如，在一类被称为“末端停止”的神经元中，增加条反应区域之外的刺激长度到周围抑制反应。目前还不清楚这些属性是否存在的感受野包围在小鼠。我们使用双光子钙成像技术研究了小鼠初级视皮层2/3层神经元的环绕调制。我们发现，在17%的视觉反应神经元中，环绕抑制是显着不对称的。此外，不对称性的大小与取向选择性相关。我们的研究结果表明，在小鼠初级视觉皮层的神经元是差异敏感的元素，在周围，个别神经元可以被描述为均匀抑制的周围，结束停止，或side-stopped.NEW & NOTEWORTHY视觉场景的感知需要积极整合本地和全球的功能，成功地分割对象从背景。虽然感知推理的底层电路和发展还没有得到很好的理解，但越来越多的证据表明，环绕调制的不对称性和多样性可能是这些计算的基础。我们确定这些关键特征存在于小鼠中。我们的研究结果支持小鼠作为一个模型，探索神经基础和发展的环绕调制，因为它涉及到知觉推理。
Complex receptive field characteristics, distributed across a population of neurons, are thought to be critical for solving perceptual inference problems that arise during motion and image segmentation. For example, in a class of neurons referred to as “end-stopped,” increasing the length of stimuli outside of the bar-responsive region into the surround suppresses responsiveness. It is unknown whether these properties exist for receptive field surrounds in the mouse. We examined surround modulation in layer 2/3 neurons of the primary visual cortex in mice using two-photon calcium imaging. We found that surround suppression was significantly asymmetric in 17% of the visually responsive neurons examined. Furthermore, the magnitude of asymmetry was correlated with orientation selectivity. Our results demonstrate that neurons in mouse primary visual cortex are differentially sensitive to the addition of elements in the surround and that individual neurons can be described as being either uniformly suppressed by the surround, end-stopped, or side-stopped.NEW & NOTEWORTHYPerception of visual scenes requires active integration of both local and global features to successfully segment objects from the background. Although the underlying circuitry and development of perceptual inference is not well understood, converging evidence indicates that asymmetry and diversity in surround modulation are likely fundamental for these computations. We determined that these key features are present in the mouse. Our results support the mouse as a model to explore the neural basis and development of surround modulation as it relates to perceptual inference.