The clinical manifestation, survival outcome and predictive prognostic factors of 137 patients with primary gastrointestinal lymphoma (PGIL): Strobe compliant.
The clinical manifestation, survival outcome and predictive prognostic factors of 137 patients with primary gastrointestinal lymphoma (PGIL): Strobe compliant.
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DOI：
10.1097/md.0000000000009583
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发表时间：
2018-01
期刊：
影响因子：
1.6
通讯作者：
Tang X
中科院分区：
文献类型：
--
作者：
Shi Z;Ding H;Shen QW;Lu XG;Chen JY;Chen X;Tang X
本回顾性研究旨在探讨中国人群原发性胃肠道淋巴瘤（PGIL）的临床特征和预后因素。从2001年1月至2015年12月，招募了137名诊断为PGIL的患者。分析其临床特征、治疗和随访信息。患者年龄中位数为62.3岁。随访18.47个月，2年无进展生存率和总生存率分别为74.9%和75.5%。总有效率为33.6%。单因素分析显示，年龄≥60岁、Lugano分期≥ IIE、乳酸脱氢酶（LDH）水平升高、淋巴结外受累部位≥2个、NCCN-IPI ≥4、Ki-67≥50%与预后不良相关（P <.05）。 通过多变量分析，我们确定淋巴结外受累部位的受累是PGIL中唯一具有统计学意义的不良预后因素。年龄、分期、LDH水平、NCCN-IPI、Ki-67尤其是多个淋巴结外部位受累与PGIL总生存率相关。
This retrospective study aimed to investigate clinical characteristics and prognostic factors in patients with primary gastrointestinal lymphoma (PGIL) of Chinese population. From January 2001 to December 2015, 137 patients diagnosed with PGIL were recruited. The clinical features, treatment, and follow-up information were analysed. The median patient age was 62.3 years. With 18.47 months follow-up, the 2-year progress-free survival and overall survival rate was 74.9% and 75.5%, respectively. The overall response rate was 33.6%. Age≥60 years, advanced Lugano staging (≥stage IIE), elevated lactate dehydrogenase (LDH) levels, ≥2 extra-nodal involved sites, National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI)≥4, Ki-67≥50% were associated with worse prognosis in univariate analysis (P < .05). By multivariate analyses, we determined that the involvement of extra-nodal involved sites was the only statistically significant poor prognostic factor in PGIL. Age, staging, LDH levels, NCCN-IPI, Ki-67 especially involvement of multiple extra-nodal sites were associated with poor overall survival of PGIL.