Nodular mixed cell lymphoma with monoclonal gammopathy.
Nodular mixed cell lymphoma with monoclonal gammopathy.
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结节性混合细胞淋巴瘤伴单克隆丙种球蛋白病。
DOI：
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发表时间：
1981
影响因子：
3.5
通讯作者：
A. Belch
中科院分区：
文献类型：
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作者：
G. O. Bain;A. Belch
恶性淋巴瘤很少伴有血清M成分。这类肿瘤通常为淋巴细胞型，除极少数例外，为弥漫型。1例罕见的混合细胞型恶性淋巴瘤患者，其特征为滤泡结构和血管增生，发现血清单克隆丙种球蛋白病（IgM κ）超过4 g/dl。苯丁酸氮芥可使M蛋白明显减少，并伴有缓解。随后复发的特点是出现了一个大细胞淋巴瘤与IgM κ表面免疫球蛋白。血清M组分无伴随性升高伴复发。
Malignant lymphomas are rarely accompanied by a serum M component. Such neoplasms are usually of lymphocytic cell type and, with extremely rare exceptions, of diffuse pattern. A patient with an unusual malignant lymphoma of mixed cell type characterized by follicular structures and vascular proliferation was found to have a serum monoclonal gammopathy (IgM kappa) of over 4 g/dl. Remission accompanied by a pronounced reduction in the M protein was achieved with Chlorambucil. Subsequent relapse was characterized by the emergence of a large cell lymphoma with IgM kappa surface immunoglobulin. No concomitant rise in the serum M component accompanied relapse.