Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring
Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring
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DOI：
10.1016/j.jpsychires.2003.10.001
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发表时间：
2004-05-01
影响因子：
4.8
通讯作者：
Boksa, P
中科院分区：
文献类型：
--
作者：
Fortier, ME;Joober, R;Boksa, P
精神分裂症发病率的增加与几种围产期侮辱有关，最明显的是孕期母体感染和围产期缺氧。这项研究使用了一个大鼠模型来直接测试母亲在怀孕期间暴露于细菌内毒素(脂多糖)是否会改变成年后的后代与精神分裂症相关的行为。这项研究还测试了产后缺氧与孕期内毒素暴露是否相互作用，从而影响行为。成年后，在怀孕第18天和第19天注射脂多糖的母鼠的后代与生理盐水处理的母鼠相比，苯丙胺诱导的运动量显著增加。出生后第7天缺氧一段时间对苯丙胺诱导的小鼠运动没有影响，孕期内毒素和出生后缺氧对这一行为的影响没有交互作用。与盐水处理的水坝后代相比，成年后，来自内毒素处理的水坝的后代也表现出更强的声学惊吓反应。在被测试的子代中，没有观察到妊娠和出生后缺氧的影响，也没有观察到内毒素和缺氧之间的相互作用。因此，孕期母鼠暴露于内毒素可作为研究母体感染对子代精神分裂症相关行为影响机制的有效模型。(C)2003爱思唯尔有限公司。保留所有权利。
An increased incidence of schizophrenia has been associated with several perinatal insults, most notably maternal infection during pregnancy and perinatal hypoxia. This study used a rat model to directly test if maternal exposure to bacterial endotoxin (lipopolysaccharide, LPS) during pregnancy alters behaviors relevant to schizophrenia, in offspring at adulthood. The study also tested if postnatal anoxia interacted with gestational LPS exposure to affect behavior. At adulthood, offspring from dams administered LPS on days 18 and 19 of pregnancy showed significantly increased amphetamine-induced locomotion, compared to offspring from saline-treated dams. A period of anoxia on postnatal day 7 had no effect on amphetamine-induced locomotion and there was no interaction between effects of gestational LPS and postnatal anoxia on this behavior. Offspring from LPS-treated dams also showed enhanced acoustic startle responses as adults, compared to offspring from saline-treated dams. In offspring tested for pre-pulse inhibition (PPI) of acoustic startle and for apomorphine modulation of PPI, no effects of either gestational LPS or of postnatal anoxia and no interactions between LPS and anoxia were observed. It is concluded that maternal LPS exposure during pregnancy in the rat may be a useful model to study mechanisms responsible for effects of maternal infection on behaviors relevant to schizophrenia, in offspring. (C) 2003 Elsevier Ltd. All rights reserved.