The Active Constituents of Ergot: A Pharmacological and Chemical Study *1
The Active Constituents of Ergot: A Pharmacological and Chemical Study *1
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麦角的活性成分：药理和化学研究*1
DOI：
10.1002/jps.3080240111
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发表时间：
1935
期刊：
影响因子：
--
通讯作者：
M. R. Thompson
中科院分区：
文献类型：
--
作者：
M. R. Thompson
一个帐户是给广泛的药理学和化学研究的活性成分麦角黑麦[麦角菌purpurea：见下一个摘要]。观察到的麦角的水提取物的功效必须存在于除麦角毒素和麦角胺之外的一些迄今未知的高度重要的活性成分中[R.A.M.，动物实验表明，这种新的生物碱与上述两种成分密切相关，其主要区别在于其更易溶的性质和口服后更迅速和更强的催产作用。麦角的非特异性氨基碱，如组胺，酪胺，发现胆碱等对药物的特征催产活性没有任何有价值的贡献。
An account is given of extensive pharmacological and chemical studies on the active constituents of ergot of rye [Claviceps purpurea: see next abstract]. The observed efficacy of the aqueous extracts of ergot must reside in some hitherto unknown, highly important active principle other than ergotoxin and ergotamin [R.A.M., xiv, p. 362], since the latter are not freely extractable in water but only in alcoholic solutions, This new alkaloid has been shown by animal experiments to be closely related to the two above-mentioned constituents, from which it differs mainly in its much more soluble nature and its more prompt and powerful oxytocic action following oral administration.The non-specific amino bases of ergot, such as histarnin, tyramin, cholins, and the like, were found to contribute nothing of value to the characteristic oxytocic activity of the drug.