Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor.
Long-term outcomes of liver transplantation in patients with hepatitis C infection are not affected by HCV positivity of a donor.
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DOI：
10.1186/s12876-016-0551-z
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发表时间：
2016-11-15
影响因子：
2.4
通讯作者：
Younossi ZM
中科院分区：
文献类型：
--
作者：
Stepanova M;Sayiner M;de Avila L;Younoszai Z;Racila A;Younossi ZM
对 HCV 阳性受者使用 HCV 阳性肝脏变得越来越普遍。我们的目的是评估接受 HCV 抗体阳性器官移植的肝移植受者的长期结果。我们从移植受者科学登记处（1995-2013）中选择了所有患有 HCV 的成年肝移植受者，并横断面比较了 HCV 抗体阳性（HCV+）与 HCV 抗体阴性供体移植者之间的长期移植物损失和死亡率。我们纳入了 33,668 名 HCV+ 肝移植受者（54.0±7.7 岁，74.1% 男性，71.0% 白人，23.6% 患有肝脏恶性肿瘤）。其中，5.7% (N = 1930) 是从 HCV+ 供体移植的；这一比例从 1995 年的 2.9% 逐渐增加到 2013 年的 9.4%。从 HCV+ 阳性供体移植的患者更有可能在移植后存活出院（95.4% vs. 93.9%，p = 0.006），但这种差异完全是由最近研究年份中 HCV+ 供体比例较高所致（调整后 p = 0.10）移植年）。移植后，HCV+供体移植的HCV患者死亡率（1年12.5%，3年24.2%，5年33.0%）和移植物丢失率（1年2.2%，3年4.8%，5年7.5%）与HCV阴性供体移植的HCV患者相似（全部p > 0.05）。在过去的二十年里，使用 HCV+ 器官进行肝移植的数量增加了两倍。尽管如此，从 HCV+ 供体移植的 HCV+ 肝移植受者的长期结果与移植 HCV 阴性器官的受者没有不同。本文的在线版本 (doi:10.1186/s12876-016-0551-z) 包含补充材料，可供授权用户使用。
The use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients transplanted with HCV antibody-positive organs. From the Scientific Registry of Transplant Recipients (1995–2013), we selected all adult liver transplant recipients with HCV, and cross-sectionally compared long-term graft loss and mortality rates between those who were transplanted from HCV antibody-positive (HCV+) vs. HCV antibody-negative donors. We included 33,668 HCV+ liver transplant recipients (54.0 ± 7.7 years old, 74.1% male, 71.0% white, 23.6% with liver malignancy). Of those, 5.7% (N = 1930) were transplanted from HCV+ donors; the proportion gradually increased from 2.9% in 1995 to 9.4% in 2013. Patients who were transplanted from HCV+ positive donors were more likely to be discharged alive after transplantation (95.4% vs. 93.9%, p = 0.006), but this difference was completely accounted for by a greater proportion of HCV+ donors in more recent study years (p = 0.10 after adjustment for the transplant year). After transplantation, both mortality in HCV patients transplanted from HCV+ donors (12.5% in 1 year, 24.2% in 3 years, 33.0% in 5 years) and the graft loss rate (2.2% in 1 year, 4.8% in 3 years, 7.5% in 5 years) were similar to those in HCV patients transplanted from HCV-negative donors (all p > 0.05). Over the past two decades, the use of HCV+ organs for liver transplantation has tripled. Despite this, the long-term outcomes of HCV+ liver transplant recipients transplanted from HCV+ donors were not different from those who were transplanted with HCV-negative organs. The online version of this article (doi:10.1186/s12876-016-0551-z) contains supplementary material, which is available to authorized users.
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影响因子：
0.9
作者：
Alvaro, E.;Abradelo, M.;Jimenez, C.
通讯作者：
Jimenez, C.
影响因子：
6.7
作者：
Saab, Sammy;Greenberg, Adam;Busuttil, Ronald W.
通讯作者：
Busuttil, Ronald W.
影响因子：
3.1
作者：
Stepanova, Maria;Younossi, Zobair M.
通讯作者：
Younossi, Zobair M.
影响因子：
6.2
作者：
Ballarin, Roberto;Cucchetti, Alessandro;Gerunda, Giorgio Enrico
通讯作者：
Gerunda, Giorgio Enrico
影响因子：
2.6
作者：
Burr, Andrew T.;Li, YouFu;Shah, Shimul A.
通讯作者：
Shah, Shimul A.