Dual effects of fibroblast growth factor 21 on hepatic energy metabolism
Dual effects of fibroblast growth factor 21 on hepatic energy metabolism
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DOI：
10.1530/joe-15-0334
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发表时间：
2015-10-01
影响因子：
4
通讯作者：
Tsintzas, Kostas
中科院分区：
文献类型：
--
作者：
Samms, Ricardo J.;Murphy, Michelle;Tsintzas, Kostas
本研究旨在探讨成纤维细胞生长因子21 （FGF21）影响西伯利亚仓鼠碳水化合物和脂肪代谢肝脏整合的机制。将12只年龄匹配的成年雄性西伯利亚仓鼠随机分为两组，连续输注生理盐水（n=6）或重组人FGF21蛋白（每天1 mg/kg， n=6），持续14天。FGF21可导致40%的抑制(P
The aim of this study was to investigate the mechanisms by which fibroblast growth factor 21 (FGF21) affects hepatic integration of carbohydrate and fat metabolism in Siberian hamsters, a natural model of adiposity. Twelve aged matched adult male Siberian hamsters maintained in their long-day fat state since birth were randomly assigned to one of two treatment groups and were continuously infused with either vehicle (saline; n=6) or recombinant human FGF21 protein (1 mg/kg per day; n=6) for 14 days. FGF21 administration caused a 40% suppression (P