Metabolic Response of Aged Men to Testosterone Propionate12
Metabolic Response of Aged Men to Testosterone Propionate12
复制标题
老年男性对丙酸睾酮的代谢反应12
DOI：
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发表时间：
1942
期刊：
影响因子：
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通讯作者：
I. Sandiford
中科院分区：
文献类型：
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作者：
A. Kenyon;K. Knowlton;G. Lotwin;I. Sandiford
In 1889 brown-sequard (1), then 72 years old, injected a testicular extract into himself and experienced a return of his youthful sense of well-being. Since this historically important, though unreliable experiment, Brown-Sequard's guiding idea that the testis might play some decisive role in SO-matic senescence has never been entirely lost sight of, even though it has acquired little substantial support. Such a role demands that the testicular hormone exert some important metabolic effect upon non-genital tissues, that hormone secretion be reduced during the declining years and that aged tissue retain sufficient sensitivity to the hormone to make any deficit in secretion one of material consequence. It is now apparent that testosterone propionate, when given intramuscularly to the hypogonad or normal man or woman, exerts metabolic influences which are compatible with the formation of new non-genital tissue (2–5). Methyl testosterone given orally evokes much the same response, although some differences in...
