Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation.
Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation.
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发表时间：
2014-05
影响因子：
2
通讯作者：
K. Kishimoto;S. Yoshida;S. Ibaragi;Norie Yoshioka;G. Hu;A. Sasaki
中科院分区：
文献类型：
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作者：
K. Kishimoto;S. Yoshida;S. Ibaragi;Norie Yoshioka;G. Hu;A. Sasaki
背景血管生成素在内皮细胞和癌细胞中经历核转位并刺激核糖体RNA转录。因此，血管生成素通过诱导血管生成和癌细胞增殖对癌症进展具有双重作用。本研究的目的是评估新霉胺，血管生成素核转位的阻断剂，是否对口腔癌具有抗肿瘤活性。材料与方法采用体内外实验方法研究新霉胺对口腔癌细胞的抑制作用。结果新霉胺对HSC-2的增殖有抑制作用，但对SAS口腔癌细胞的增殖无明显影响。用新霉胺处理有效地抑制HSC-2和SAS细胞异种移植物在无胸腺小鼠中的生长。新霉胺治疗导致肿瘤血管生成显著减少，伴随着血管生成素和增殖细胞核抗原阳性癌细胞的减少，特别是HSC-2肿瘤。结论新霉胺通过抑制肿瘤血管生成，有效抑制口腔癌的发生发展。新霉胺还直接抑制某些类型的口腔癌细胞的增殖。因此，新霉胺具有作为口腔癌治疗的先导化合物的潜力。
BACKGROUND Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer. MATERIALS AND METHODS The antitumor effect of neamine on oral cancer cells was examined both in vitro and in vivo. RESULTS Neamine inhibited the proliferation of HSC-2, but not that of SAS oral cancer cells in vitro. Treatment with neamine effectively inhibited growth of HSC-2 and SAS cell xenografts in athymic mice. Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin- and proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors. CONCLUSION Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy.