Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon
Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon
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DOI：
10.14670/hh-22.251
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发表时间：
2007-03-01
影响因子：
2
通讯作者：
Tatematsu, M.
中科院分区：
文献类型：
--
作者：
Mizoshita, T.;Tsukamoto, T.;Tatematsu, M.
目的：我们以前已经证明了临床病理学发现和表型之间的联系，在胃癌和胰腺癌中使用几种胃和肠表型标记物。然而，表型和Cdx 2表达的临床病理意义迄今仍不清楚在结直肠癌发生。方法和结果：我们研究了91例原发性早期结肠癌中胃肠表型表达的相关性。MUC 2的表达从伴有中度浸润的管状/管状绒毛状腺瘤到粘膜内癌再到伴有粘膜下浸润的癌均显著降低（P < 0.0001）。粘膜内原发性癌（无腺瘤成分的扁平型癌）的MUC 2下降幅度大于有腺瘤成分的粘膜内病变。MUC 5AC的表达也随着管状/管状绒毛腺瘤序列的进展而显著降低，与管状腺瘤相比，具有绒毛腺瘤成分的癌具有更高的水平，这表明恶性转化途径的差异。Cdx 2核表达维持在所有的腺瘤和早期癌检查。结论：我们的数据表明，MUC 2表达的减少可能与腺瘤-癌序列途径和原发性癌的发生和发展有关。Cdx 2的肿瘤抑制作用可能在结直肠癌发生的早期阶段保留。
Aims: We have previously demonstrated links between clinicopathological findings and phenotypes using several gastric and intestinal phenotypic markers in stomach and pancreatic cancers. However, the clinicopathological significance of the phenotype and Cdx2 expression has hitherto remained unclear in colorectal carcinogenesis. Methods and results: We examined the correlation between gastric and intestinal phenotypic expression in 91 primary early carcinomas of the colon. MUC2 expression demonstrated a significant decrease from tubular/ tubulovillous adenomas with moderate atypia, through intramucosal carcinomas, to cancers with submucosal invasion (P < 0.0001). Intramucosal de novo carcinomas ( flat type carcinomas without adenomatous components) exhibited a greater decrease of MUC2 than intramucosal lesions with adenomatous components. Expression of MUC5AC also decreased significantly with progression according to the tubular/ tubulovillous adenomacarcinoma sequence, carcinomas with villous adenomatous components having a higher level compared with their tubular adenomatous counterparts, suggesting differences in the pathway of malignant transformation. Cdx2 nuclear expression was maintained in all of the adenomas and early carcinomas examined. Conclusions: Our data suggest that the reduction of MUC2 expression may be associated with the occurrence and progression of colorectal carcinomas in both adenoma- carcinoma sequence pathway and de novo carcinogenesis. Tumor- suppressive effects of Cdx2 may be preserved during early stages of colorectal carcinogenesis.