Structure and Function of IP3 Receptors
Structure and Function of IP3 Receptors
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DOI：
10.1101/cshperspect.a035063
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发表时间：
2019-04-01
影响因子：
7.2
通讯作者：
Taylor, Colin W.
中科院分区：
文献类型：
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作者：
Prole, David L.;Taylor, Colin W.
肌醇1,4,5-三磷酸受体（IP(3)Rs）通过从动物细胞的内质网（ER）释放Ca2+，允许Ca2+从内质网重新分配到细胞器或其他细胞器，并启动储存操作的Ca2+进入（SOCE）。对于所有三种IP3R亚型，IP3的结合使它们与Ca2+结合，然后触发通道打开。我们现在已经接近了解IP3R激活的结构基础。由IP3调控的Ca2+诱导的Ca2+释放允许IP(3)Rs再生传播Ca2+信号。这些再生事件中最小的是Ca2+泡发，这是由一小簇IP(3)Rs几乎同时打开引起的。Ca2+泡是所有IP3诱发的Ca2+信号的基本组成部分，但只有一些IP3簇，即那些位于SOCE发生的er -质膜连接处的IP3簇，被许可做出反应。这些许可的IP(3)Rs的位置可能允许他们有选择地调节SOCE。
Inositol 1,4,5-trisphosphate receptors (IP(3)Rs), by releasing Ca2+ from the endoplasmic reticulum (ER) of animal cells, allow Ca2+ to be redistributed from the ER to the cytosol or other organelles, and they initiate store-operated Ca2+ entry (SOCE). For all three IP3R subtypes, binding of IP3 primes them to bind Ca2+, which then triggers channel opening. We are now close to understanding the structural basis of IP3R activation. Ca2+-induced Ca2+ release regulated by IP3 allows IP(3)Rs to regeneratively propagate Ca2+ signals. The smallest of these regenerative events is a Ca2+ puff, which arises from the nearly simultaneous opening of a small cluster of IP(3)Rs. Ca2+ puffs are the basic building blocks for all IP3-evoked Ca2+ signals, but only some IP3 clusters, namely those parked alongside the ER-plasma membrane junctions where SOCE occurs, are licensed to respond. The location of these licensed IP(3)Rs may allow them to selectively regulate SOCE.