Prevalence of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome.
Prevalence of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome.
复制标题
患有和不患有获得性免疫缺陷综合症的同性恋男性肠道病原体的患病率。
DOI：
10.1016/0016-5085(88)90557-4
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发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Bartlett,JG
中科院分区：
文献类型：
--
作者：
Laughon,BE;Druckman,DA;Vernon,A;Quinn,TC;Polk,BF;Modlin,JF;Yolken,RH;Bartlett,JG
我们研究了388名来自巴尔的摩-华盛顿地区的同性恋或双性恋男性，以确定与人类免疫缺陷病毒感染相关的“同性恋肠道综合征”高危人群中肠道病原体携带谱。77例获得性免疫缺陷综合征患者，68例有急性腹泻或直肠炎症状的男同性恋者，243例无胃肠道症状并参与人类免疫缺陷病毒感染自然史研究的男同性恋者被选入研究。大约12%的无症状男性至少携带一种肠道病原体，最常见的是沙眼衣原体、单纯疱疹病毒和贾第鞭毛虫。携带病原体的男性比不携带病原体的男性（25%）更可能是人类免疫缺陷病毒血清阳性（48%）（p = 0.018），更可能有较少的T辅助细胞（p = 0.015），更可能有粘液脓性渗出物（p = 0.014）。我们从68%患有腹泻或直肠炎的男同性恋者中发现了一种肠道疾病病原体。弯曲杆菌属、单纯疱疹病毒、淋病奈瑟菌、C。trachomatis、G.最常见的是Iamblia和Shigella种。与获得性免疫缺陷综合征腹泻相关的最常见病原体为隐孢子虫（16%）。其他病原体包括艰难梭菌、副溶血性弧菌、弯曲杆菌、G.蓝氏菌属、等孢菌属和巨细胞病毒。在获得性免疫缺陷综合征患者腹泻的可识别病原体中，约有一半可用抗生素治疗，但这些病原体需要特殊的培养程序进行检测。
We studied 388 homosexual or bisexual men from the Baltimore-Washington area to define the spectrum of enteric pathogen carriage in a population at high risk for “gay bowel syndrome” in association with human immunodeficiency virus infection. Seventy-seven patients with acquired immunodeficiency syndrome, 68 gay men with symptoms of acute diarrhea or proctitis, and 243 gay men without gastrointestinal symptoms and participating in a natural history study of human immunodeficiency virus infection were selected for study. Approximately 12% of the asymptomatic men harbored at least one enteric pathogen; the most frequently recovered wereChlamydia trachomatis, herpes simplex virus, andGiardia lamblia. Men carrying a pathogen were more likely to be human immunodeficiency virus seropositive (48%) than men without a pathogen (25%) (p = 0.018), more likely to have fewer T helper cells (p = 0.015), and more likely to have a mucopurulent exudate (p = 0.014). We recovered an agent of enteric disease from 68% of gay men presenting with diarrhea or proctitis.Campylobacterspecies, herpes simplex virus,Neisseria gonorrhoeae, C. trachomatis, G. Iamblia, andShigellaspecies were identified most frequently. The most common pathogen associated with diarrhea in acquired immunodeficiency syndrome wasCryptosporidium(16% of 49 cases). Other agents identified wereClostridium difficile, Vibrio parahemolyticus, Campylobacterspecies,G. lamblia, Isospora, and cytomegalovirus. Approximately half of the identifiable etiologic agents of diarrhea in acquired immunodeficiency syndrome patients were treatable With antibiotics, but these agents required special culture procedures for detection.