First evidence of prenatal exposure to emerging poly- and perfluoroalkyl substances associated with e-waste dismantling: Chemical structure-based placental transfer and health risks
First evidence of prenatal exposure to emerging poly- and perfluoroalkyl substances associated with e-waste dismantling: Chemical structure-based placental transfer and health risks
复制标题
产前接触与电子废物拆解相关的新兴多氟烷基物质的第一个证据：基于化学结构的胎盘转移和健康风险
DOI：
10.1021/acs.est.2c05925
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Tao Zhang
中科院分区：
文献类型：
--
作者：
Bo Zhang;Ziyang Wei;Cheng Gu;Yiming Yao;Jingchuan Xue;Hongkai Zhu;Kurunthachalam Kannan;Hongwen Sun;Tao Zhang
Limited information is available about prenatal exposure to per- and polyfluoroalkyl substances (PFAS) in electronic waste (e-waste) recycling sites. In this study, we determined 21 emerging PFAS and 13 legacy PFAS in 94 paired maternal and cord serum samples collected from an e-waste dismantling site in Southern China. We found 6:2 fluorotelomer sulfonate (6:2 FTSA), 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), and perfluorooctanephosphonate (PFOPA) as the major emerging PFAS, regardless of matrices, at median concentrations of 2.40, 1.78, and 0.69 ng/mL, respectively, in maternal serum samples, and 2.30, 0.73, and 0.72 ng/mL, respectively, in cord serum samples. Our results provide evidence that e-waste dismantling activities contribute to human exposure to 6:2 FTSA, 6:2 Cl-PFESA, and PFOPA. The trans-placental transfer efficiencies of emerging PFAS (0.42–0.94) were higher than that of perfluorooctanesulfonic acid (0.37) and were structure-dependent. The substitution of fluorine with chlorine or hydrogen and/or hydrophilic functional groups may alter trans-placental transfer efficiencies. Multiple linear regression analysis indicated significant associations between maternal serum concentrations of emerging PFAS and maternal clinical parameters, especially liver function and erythrocyte-related biomarkers. This study provides new insights into prenatal exposure to multiple PFAS in e-waste dismantling areas and the prevalence of emerging PFAS in people living near the sites.
