Skeletal Muscle Strength in Young Asian Indian Females after Vitamin D and Calcium Supplementation: A Double-Blind Randomized Controlled Clinical Trial
Skeletal Muscle Strength in Young Asian Indian Females after Vitamin D and Calcium Supplementation: A Double-Blind Randomized Controlled Clinical Trial
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DOI：
10.1210/jc.2012-2340
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发表时间：
2012-12-01
影响因子：
5.8
通讯作者：
Bhatia, Himani
中科院分区：
文献类型：
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作者：
Goswami, Ravinder;Vatsa, Manju;Bhatia, Himani
内容：补充维生素D/钙对骨骼肌力量影响的随机对照试验（RCT）在老年人中没有显示出有希望的效果。目的：我们的目的是评估维生素D和/或钙对维生素D缺乏的年轻人肌肉力量的影响。设计和设置：我们于2010年9月至2011年4月在一家三级护理中心采用析因设计进行了一项RCT。受试者：共有173名健康女性，平均年龄、体重指数和25-羟基维生素D [25（OH）D]为21.7 ± 4.4岁，20.8 ± 2.96 kg/m2，和9.3 +/-3.37 ng/ml分别被区组随机分为1）双安慰剂，2）钙/安慰剂，3）胆钙化醇/安慰剂，和4）胆钙化醇/钙6个月。胆钙化醇以60，000 IU/周的剂量给药8周，随后以60，000 IU/周的剂量给药。元素钙500 mg，每日2次，疗程6个月（主要结果）和捏握力、6分钟步行距离、呼吸困难评分、健康调查简表（SP-36）生活质量、血清25（OH）D、1，25-二羟维生素D和完整PTH。两组血清25（OH）D显著升高至29.9 +/- 8.35和27.0 +/- 9.54 ng/ml。平均手握力（19.4 +/- 3.92、21.1 +/- 3.31、20.6 +/- 3.92和20.1 +/- 4.00 kg）及其较基线的增加在6个月时，四个组的体重（0.3 +/- 2.25、0.3 +/- 2.64、+/- 0.3 +/- 2.41和0.6 +/- 2.30 kg）相当。生活质量，尿钙/肌酐比值，和不良反应也是可比的groups.Conclusion：口服胆钙化醇/钙补充剂的剂量/时间表使用是有效的和安全的增加和维持血清25（OH）D。然而，这并不能改善年轻女性的骨骼肌力量。（临床内分泌代谢杂志97：4709-4716，2012）
Context: Randomized control trials (RCT) of the effect of vitamin D/calcium supplementation on skeletal muscle strength have not shown promising effect in the elderly.Objective: Our objective was to assess the effect of vitamin D and/or calcium on muscle strength in young adults with vitamin D deficiency.Design and Setting: We conducted a RCT using a factorial design at a tertiary-care center from September 2010 to April 2011.Subjects: A total of 173 healthy females with mean age, body mass index, and 25-hydroxyvitamin D [25(OH)D] of 21.7 +/- 4.4 yr, 20.8 +/- 2.96 kg/m(2), and 9.3 +/- 3.37 ng/ml, respectively, were block randomized to 1) double placebo, 2) calcium/placebo, 3) cholecalciferol/placebo, and 4) cholecalciferol/calcium for 6 months. Cholecalciferol was given at 60,000 IU/wk for 8 wk followed by 60,000 IU/fortnight. Elemental calcium was given in doses of 500 mg twice per day for 6 months.Methods: Assessment included hand grip (primary outcome) and pinch grip strength, distance walked in 6 min, dyspnea score, quality of life by Short Form (36) Health Survey (SP-36), serum 25(OH) D, 1,25-dihydroxyvitamin D, and intact PTH.Results: The serum 25(OH) D increased significantly to 29.9 +/- 8.35 and 27.0 +/- 9.54 ng/ml in two groups on cholecalciferol. The mean hand grip strength (19.4 +/- 3.92, 21.1 +/- 3.31, 20.6 +/- 3.92, and 20.1 +/- 4.00 kg) and its increase from baseline (0.3 +/- 2.25, 0.3 +/- 2.64, +/- 0.3 +/- 2.41, and 0.6 +/- 2.30 kg) were comparable in four groups at 6 months. Quality of life, urinary calcium/creatinine ratio, and adverse effects were also comparable in groups.Conclusion: Oral cholecalciferol/calcium supplementation in the dose/schedule used is effective and safe in increasing and maintaining serum 25(OH)D. However, this does not lead to improved skeletal muscle strength in young females. (J Clin Endocrinol Metab 97: 4709-4716, 2012)