Platelet adhesion to damaged coronary arteries: Comparison in normal and von Willebrand disease swine.
Platelet adhesion to damaged coronary arteries: Comparison in normal and von Willebrand disease swine.
复制标题
血小板粘附到受损冠状动脉：正常猪和冯维勒布兰德病猪的比较。
DOI：
10.1073/pnas.79.16.5076
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发表时间：
1982
影响因子：
11.1
通讯作者：
Brinkhous,KM
中科院分区：
文献类型：
--
作者：
Reddick,RL;Griggs,TR;Lamb,MA;Brinkhous,KM
在正常猪和患有血管性血友病（vWD）的猪中研究了对冠状动脉损伤的早期反应。冠状动脉内皮剥脱后三十分钟，放血猪和正常猪的简单损伤区域均粘附有单层血小板。两种表型中粘附的血小板数量没有显着差异。涉及血管中膜的损伤产生血小板纤维蛋白血栓。根据伪足形成和血小板在简单损伤区域的扩散来判断，放血动物的血小板活化明显低于正常动物。这些研究表明血小板对受损动脉壁的趋化性和初始接触粘附与冯·维勒布兰德因子无关。另一方面，血小板在内皮下的扩散和激活似乎依赖于血浆冯维勒布兰德因子的存在。通过这种机制，血管性血友病因子可能导致动脉血栓形成和动脉粥样硬化。
The early response to coronary artery injury was investigated in normal swine and in swine with von Willebrand disease (vWD). Thirty minutes after coronary endothelial denudation, a monolayer of platelets was adherent to areas of simple injury in both bleeder and normal swine. The number of adherent platelets was not significantly different in the two phenotypes. Injury involving the media of the vessel produced platelet-fibrin thrombi. Platelet activation, as judged by pseudopod formation and platelet spreading over areas of simple injury, was significantly less in bleeder animals than in normal animals. These studies suggest that chemotaxis and initial contact adhesion of platelets to injured arterial wall is independent of the von Willebrand factor. On the other hand, the spreading and activation of platelets on the subendothelium appear to be dependent on the presence of plasma von Willebrand factor. Through this mechanism von Willebrand factor may contribute to arterial thrombosis and atherogenesis.