Cubene (1,2-dehydrocubane)
Cubene (1,2-dehydrocubane)
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立方烯（1,2-脱氢立方烷）
DOI：
10.1021/ja00229a057
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发表时间：
1988
影响因子：
15
通讯作者：
M. Maggini
中科院分区：
文献类型：
--
作者：
P. Eaton;M. Maggini
以40%的总收率合成了1，2-二碘立方烷（方案I）。第一个步骤遵循我们先前的论证，即立方烷酰胺的邻位锂化在很小程度上进行，并且可以通过采用金属转移过程来合成有用的。因此，立方烷羧酸的酰胺衍生物8通过锂化立方烷9以高产率转化为有机汞10，然后不经后处理直接通过与碘反应得到碘代酰胺11。水解
1, 2-Diiodocubane was synthesized in 40% overall yield (Scheme I). The first steps follow from our previous demonstration that ortho-lithiation of cubane amides proceeds to a small degree and can be made synthetically useful by employing transmetalation processes. 18 Thus, the amide derivative 8 of cubane carboxylic acid is converted in high yield via the lithiated cubane 9 to the organomercury 10 which is then taken directly without workup to theiodoamide 11 by reaction with iodine. Hydrolysis of the