Catalytic atropo-enantioselective reduction of biaryl lactones to axially chiral biaryl compounds
Catalytic atropo-enantioselective reduction of biaryl lactones to axially chiral biaryl compounds
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DOI：
10.1021/ol800802c
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发表时间：
2008-06-19
期刊：
影响因子：
5.2
通讯作者：
Yamada, Tohru
中科院分区：
文献类型：
--
作者：
Ashizawa, Tomoko;Tanaka, Saiko;Yamada, Tohru
光学活性的β-酮亚胺钴(II)配合物催化联芳基内酯的动力学拆分反应生成光学活性联芳基化合物。对起始联芳内酯进行了不同温度下的手性高效液相色谱分析，以确定适合动态动力学拆分的反应条件。合成了多种类型的轴向手性联芳化合物，具有较高的对映体选择性。
The atropo-enantioselective borohydride reduction with dynamic kinetic resolution of biaryl lactones was catalyzed by an optically active beta-ketoiminatocobalt(II) complex to afford optically active biaryl compounds. Chiral HPLC analysis of the starting biaryl lactones was performed at various temperatures to determine suitable reaction conditions for dynamic kinetic resolution. Various types of axially chiral biaryl compounds were obtained with high enantioselectivity.